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Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

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Figure

Figure 1: Lgr5+ stem cells remain in their homeostatic location, but Lgr5 progeny repopulated the epidermal basal layer after UV overexposure in haired mice
Figure 3: Progeny of Lgr5+ stem cells is (largely) absent in skin tumors; in hairless mice progeny of Lgr5+ stem cells migrated into the IFE only after prolonged treatment (over 6 months) with carcinogenic stimuli
Figure 4: CD34 and Sox2 expression in skin tumors. Sections of tumors were stained with anti-CD34 Both chemically induced tumors in haired mice (A+B) (CD34+ 15 of 21 tumors and Sox2+ 7 of 8 tumors) as well as UV-induced tumors in hairless mice (C+D) showed

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