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Synthesis a novel DNA minor groove binding agents by bis benzimidazole

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Figure

Table 1 The anti-tumor activities of the compounds (8-15)
Figure 2. (a) Absorption Spectra of DNA-compound 8 in Tris-HCl Buffer Solution at pH 7.4CT-DNA concentration was kept fixed at 10 mM and compound 10 concentration was varied from(1) 0 to (5) 20 mM; (b) Fluorescence emission spectra (excited at 520 nm) of EB, EB-DNA complexes in the absence (1) and presence (2-6) of increasing concentrations of the compound 8 (2 mmol L-1, 1 L per scan)

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