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Lin28 mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice

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Figure

Fig. 1. Loss of Lin28a/b results in NTDs and embryonic lethality. (A) Confocal microscopy images of E11.5 wild-type embryo sectioned sagittally show Lin28aexpression across the entire neural tube
Table 1. Numbers of embryos recovered alive out of 291 embryosdissected at E8.5-E18.5 stages
Fig. 3. Lin28a−/−;Rpl24Bst/+ mutants mimic Lin28a/b double knockout phenotypes in neural tube defects (NTDs) and embryonic lethality
Fig. 4. Abnormally increased brain size and ratio of apical to intermediate NPCs in Lin28ameasurements averaged from at least three sections of each mutant embryo (-overexpressing mice are rescued by Rpl24Bst/+heterozygosity
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