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Targeting IRAK1 in T-Cell acute lymphoblastic leukemia

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Figure

Figure 1: Kinases expression profiles of human T-ALL samples and thymic subpopulations
Figure 2: IRAK1 is overexpressed and functional in T-ALL. A. qRT-PCR: IRAK1 transcriptional expression is shown in T-ALL according to TCR status, and in thymic subsets
Figure 3: Genetic knock-down of IRAK1 induces apoptosis and disrupts cell cycle. A. Genetic knockdown of IRAK1 was confirmed by western blotting in Jurkat cells expressing a control or shIRAK1-expressing lentiviral vector B
Figure 4: Genetic knockdown of IRAK1 reverses corticoresistance in Jurkat. A. AnnexinV/IP staining was assessed in Jurkat after transduction with shRNA-expressing lentiviral vector and after 72 h treatment with dexamethasone (0–100-500 μM)
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