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Cross repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear

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Figure

Fig. 1. Patterning and morphogenesis of the inner ear. Diagramsof the transformation of the otic vesicle into the mature structure of theinner ear
Fig. 2. Lrig3 ATG-bearing exon in the conditional views of the entire inner ear (G,H) reveal a truncation of the lateral semicircular canal (arrowhead, H)
Fig. 3. Lrig3 acts in the non-fusing epithelium to preventpremature and ectopic fusion
Fig. 4. The basement membrane undergoes early and ectopic breakdown in the inner ear of Lrig3basement membrane is continuous in heterozygotes (arrowheads, D,E) but is absent (asterisks, I) or severely disrupted (asterisk, J) in homozygotes.sections through
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