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Structure Function Studies of Nicotinic Acetylcholine Receptors Using Selective Agonists and Positive Allosteric Modulators

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Figure

Figure 1.2 Structural arrangements for Cys-loop receptors. (A) A representation of a single subunit depicting the homologous regions for the Cys-loop family
Figure 1.3 The power of non-canonical amino acid mutagenesis. Conventional mutagenesis of phenylalanine (Phe) is limited in structural perturbation and lacks specific control
Figure 1.5  Schematic representation of nonsense suppression methodology in Xenopusoocytes for non-canonical amino acid incorporation into ion channels
Figure 1.6  The EC50 experiment. (A) Increasing concentration of an agonist shifts more channels to the open state and creates a larger correction current for the TEVC configuration
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