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Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations

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Figure 1 Mutational spectrum of all genes with Note:>5% mutation frequency. NPM1 was the most frequently combined mutation gene (n=28, 54.9%), followed by FLT3 (n=21, 41.2%), IDH1 (n=11, 21.6%), TET2 (n=6, 11.8%), SMC3 (n=6, 11.8%), IDH2 (n=5, 9.8%), NRAS (n=5, 9.8%), KRAS (n=4, 7.8%), MT-CYB (n=4, 7.8%), CEBPA (n=3, 5.9%), PTPN11 (n=3, 5.9%), U2AF1 (n=3, 5.9%), SMC1A (n=3, 5.9%), and RAD21 (n=3, 5.9%).
Table 1 Biological and clinical characteristics
Table 2 Kaplan–Meier analysis for EFS and OS between different biological and clinical character groups
Figure 2 Comparison of EFS and OS between different biological and clinical character groups.Abbreviations:Notes: (A and B) EFS and OS of DNMT3Amut/NPM1wild vs DNMT3Amut/NPM1mut in all of the 51 patients
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