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Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents

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Academic year: 2020

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Figure

Figure 1Effect of spinal leptin on neuropathic pain behaviors.
Figure 2Increase in spinal leptin expression. (A and B) Leptin expression (Western blot) was increased after CCI in the ipsilateral (Ipsi) spinal cord dor-sal horn but not in the contralateral (Contra) spinal cord dorsal horn
Figure 3Upregulation of spinal leptin receptors. CCI increased Ob-Rb mRNA expression within the ipsilateral spinal cord dorsal horn on day 7 but not on
Figure 4Role of JAK2 and STAT3 in the spinal leptin effect. (A–D) The expression (Western blot) of JAK2, p-STAT3, NR1, and IL-1β was increased, whereas STAT3 was decreased on day 7 in CCI rats
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