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Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice

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Figure

Figure 1HSV-1 infection increases Egr-1 expression. The viral growth (A) and Egr-1 expression assayed by RT-PCR (B) and Western blot (C) analyses were monitored in SK-N-SH cells infected with strain KOS or with UV-inactivated virus (UV)
Figure 2Egr-1 increases HSV-1 replication. Growth of strain KOS in SK-N-SH cells transfected with an antisense or scramble oligomer to Egr-1 (A) or in embryonic fibroblasts (B) and brain slices (C) prepared from Egr-1+/+ or Egr-1–/– mice
Figure 4Egr-1 increases the viral loads in tissues and mortality of HSV-1–infected mice
Figure 5Inflammatory cell infiltration and neuron damage in infected mouse

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