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Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice

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Figure

Figure 1Retinal degeneration as a consequence of mutant tion of a with surrounding yellow flecks (white arrows)
Figure 2Electron microscopy of PROM1 transgenic mouse rod photorecep-tors. (A and B) Overgrown and abnormally oriented disk membranes (arrows) in PMT3 retinas were visible at 16 days (A) and 4 months (B) of age
Figure 3Immunohistochemical localization of human PROM1 PROM1 immunolocalization in PROM1 immunolabeling (OSs
Figure 4Coimmunoprecipitation of PROM1 and PCDH21 and proteolytic cleav-age of PCDH21
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