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Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain

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Figure

Figure 1. Increased numbers of astrocytic Ca2+black). Spine turnover and mechanical threshold data are from our previous study (10) conducted under the same conditions, with additional data from 1 mouse included
Figure 2. Activation of S1 astrocytic Ca2+arrowheads) show no Canm 2-photon laser stimulation (10 mW, 50-ms duration, Tornado mode, Olympus)
Figure 3. Inactivation of S1 astrocytic Ca2+ inhibits spine turnover. (A) Repeated in vivo 2-photon imaging of the same dendrites before and 3 days after drug infusion into S1 cortex
Figure 4. Astrocytic Ca2+by unpaired TSP-1 levels significantly increased following PSL injury, peaked at 3 to 6 days after injury, and subsequently decreased to baseline levels (group)
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