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Potential of High Affinity, Slow Off Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications

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Figure

TABLE 1 High-affinity SOMAmer binding reagents for M. tuberculosis proteins
FIG 1 Characterization ofdata are shown for different SOMAmer reagents selected with A85A, A85B, A85C, and MTB12
TABLE 2 LOD and LOQ for 21 top-performing M. tuberculosis SOMAmers in buffer, serum, and urine protein concentratesa
FIG 2 SOMAmer validation with native M. tuberculosis proteins. (A) SBRs for 86 M. tuberculosis aptamers at 24-h and 72-h infection time points in M.tuberculosis-infected human macrophage lysates in vitro
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