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Identification of Acute HIV 1 Infection by Hologic Aptima HIV 1 RNA Qualitative Assay

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Figure

FIG 1 Sensitivity of the Aptima assay. (A) Aptima s/co levels of HIV-1-infected individuals on ART with detectable viral loads plotted againstRNA copies/ml as determined by the Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 test
FIG 3 Representative patterns of Aptima reactivity for uninfected and HIV-1-infected participants
FIG 5 Patterns of Aptima reactivity in acute HIV-1 infection as identified by conversion from nonreactiveto reactive for detection of HIV-1 RNA within the period studied
FIG 7 Aptima s/co ratios observed in response to antiretroviral therapy (ART). Volunteer 20101 (A) showeda rapid sustained response to ART with intermittent detectable viremia before achieving virologic control,while volunteer 30166 (B) showed more typical continued sporadic low-level reactivity despite ART therapy.The dotted line represents the Aptima assay cutoff, which is an s/co of greater than or equal to 1.0.

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