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FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

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Academic year: 2020

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Figure

Figure 1: APOBEC overexpression correlates with hypermutation in lung adenocarcinoma. RNA-seq and DNA-seq mutation data sets for lung cancers were downloaded from TCGA
Figure 2: Low FHIT expression alone correlates with modest hypermutation in lung adenocarcinoma DNAs
Figure 3: A3B-high/FHIT-low lung adenocarcinoma DNAs exhibit pronounced hypermutation
Figure 4: TP53 DNA amplified from A3B-high/Fhit-low TREx 293 cells exhibit an increased frequency of C > T mutations
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