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The increased ability to present citrullinated peptides is not unique to HLA SE molecules: arginine to citrulline conversion also enhances peptide affinity for HLA DQ molecules

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Figure

Fig. 1 Accommodation of citrulline and arginine residues by HLA-DR4 and HLA-DR3 molecules
Fig. 2 Accommodation of citrulline and arginine residues by HLA-DQ molecules.peptide with an unlabeled VP16 peptide or VP16 variants with citrulline or arginine residues in p1, p4, p6, p7, and p9 to HLA-DQ7 (HLA-DQ8 ( a Schematic representation of the diff
Fig. 3 Model structures of citrulline residue accommodation in peptide-binding pockets 7 and 9 of HLA-DQ2.the same color code as the stick form residues, except for carbon, which is inand conventions as in A

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