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Generalizing boundaries for triangular designs, and efficacy estimation at extended follow ups

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Figure

Fig. 1 Flowchart outlining the assessments in a visceral leishmaniasis trial. A diagram showing the different clinical and parasitological assessmenttime points carried out and possible outcomes in a VL trial
Fig. 2 Illustration of the triangular group-sequential design.route the analysis could take
Figure 3 shows the three potential designs for the moti-vating example. One can see that the boundaries becomewider and the maximum sample size becomes larger asthe number of interim analyses is increased
Table 1 Parameter estimates for the three potential designs forthe motivating example
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