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The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells

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Figure

Figure 1: Drosophila lymph gland scheme and essential features of the drug administration protocol
Figure 2: Pharmacological inhibition and genetic loss of the smomelanotic nodules. Anterior is on the left
Figure 3: the human smo inhibitor PF-04449913 drives the increase of hemocytes in the hemolymph and of crystal
Figure 4: PF-04449913 inhibits expression of a Hh signaling target gene. (dashed lines indicate the A/P border as defined by the posterior limit of the high-level expression domain of the Ptc protein in the anterior compartment
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