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Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist

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Figure

Figure 1. Chemical structure of SR 121463A. (Inset) Structure of OPC-31260 as originally published (24).
Table I. Comparative Affinities of SR 121463A and OPC-31260 for Vasopression and Oxytocin Receptors in Animal andHuman Species
Table II. Selectivity Profile of the Two Nonpeptide AVP V2Receptor Antagonists, SR 121463A and OPC-31260, for  Human Vasopressin and Oxytocin Receptors
Figure 5. Effects of SR 121463A on cumulative urine volume (121463A (SR) or OPC-31260 (OPC) administration in a 0.6% meth-ylcellulose solution
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