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Stress Degradation Behavior of a Polypill and Development of Stability Indicating UHPLC Method for the Simultaneous Estimation of Aspirin, Atorvastatin, Ramipril and Metoprolol Succinate

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Figure

Figure 1. Chemical structures and labels of all the drug substances: ASP, ATV, RMP and MTP (a) Aspirin (ASP): (b) Atorvastatin (ATV): (3[(2propanoyl]-octahydrocyclopenta[acid M.F: Cprolol (MTP): (RS)-1-(isopropyl amino)-3-[4-(2-ethoxyethyl) phenoxy] Propan
Figure 2. Typical chromatogram of acid degradation, 0.1 N HCl (100˚C, 1 h).
Figure 3. Typical chromatogram of base degradation, 0.1 N NaOH (under reflux, 0.5 h).
Figure 4. Typical chromatogram of Peroxide degradation, 5% hydrogen peroxide (RT, 8 h)
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