organic papers
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Coelhoet al. C12H13N3O2H2O doi:10.1107/S1600536807007015 Acta Cryst.(2007). E63, o1380–o1382 Acta Crystallographica Section E
Structure Reports
Online
ISSN 1600-5368
Ethyl [3-(2-pyridyl)pyrazol-1-yl]acetate monohydrate
Ana C. Coelho, Isabel S.
Gonc¸alves and Filipe A. Almeida Paz*
Department of Chemistry, University of Aveiro, CICECO, 3810-193 Aveiro, Portugal
Correspondence e-mail: fpaz@dq.ua.pt
Key indicators
Single-crystal X-ray study T= 100 K
Mean(C–C) = 0.004 A˚ Disorder in solvent or counterion Rfactor = 0.061
wRfactor = 0.176
Data-to-parameter ratio = 12.7
For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
Received 11 January 2007 Accepted 10 February 2007
#2007 International Union of Crystallography
All rights reserved
The asymmetric unit of the title compound, C12H13N3O2H2O, comprises two crystallographically independent organic mol-ecules and two water molmol-ecules. There is an O—H N hydrogen bond between each water molecule and the 2-substituted pyridyl ring of an organic molecule. The water molecules are further engaged in disordered O—H O hydrogen bonds with each other, leading to the formation of a one-dimensional zigzag chain running parallel to thebaxis.
Comment
The synthesis of ethyl [3-(2-pyridyl)pyrazol-1-yl]acetate was first described by Thielet al.(1994), but a full crystallographic description has never been reported. Our research group has been particularly interested in its excellent N,N-chelating properties. For example, its coordination complexes with molybdenum and europium lead to chemical systems exhi-biting interesting catalytic (Coelhoet al., 2006; Bruno, Pereira
et al., 2007; Bruno, Fernandeset al., 2006; Gagoet al., 2006) and photophysical properties (Gago et al., 2005), respectively. Here, we report the crystal structure of the monohydrate of this organic compound, (I), determined at 100 (2) K.
The asymmetric unit of compound (I) comprises two essentially identical organic molecules and two water mol-ecules of crystallization, as depicted in Fig. 1. These two organic molecules are related by pseudo-translation symmetry, but the two terminal —CO2—CH2—CH3 groups, which are probably affected by some disorder (as explained in theExperimentalsection), break this potential symmetry.
The pyrazolyl and pyridyl rings associated with the two organic molecules exhibit similar geometries (Fig. 1), with the ‘free’ N atoms adopting atransconformation around C5—C6 and C17—C18 in order to minimize steric repulsion between the uncoordinated electron pairs. The resulting conformation is almost planar, the torsion angles between the two rings being 1.5 (4) for N1—C5—C6—C7 and 0.6 (4) for N4— C17—C18—C19.
of clarity, have been omitted from the Figures, but are listed in Table 1. The average distance between rings belonging to adjacent organic molecules is about 3.4 A˚ . This columnar arrangement of organic molecules has theN-donor atoms of
the 2-substituted pyridyl aromatic rings pointing towards a small channel running parallel to thebaxis and containing the water molecules of crystallization. Indeed, these N atoms act as acceptors in strong and highly directional O—H N hydrogen-bonding interactions (Table 1), which are best described by a discrete D graph-set motif (Bernstein et al., 1995). These water molecules of crystallization are further engaged in disordered O—H O hydrogen-bonding inter-actions with each other (Table 1), leading to the formation of a one-dimensional zigzag water chain which also runs along the [010] crystallographic direction, and is best described by the
C(2) graph-set motif (Fig. 2). This hydrogen-bonding network leads to the formation of Z-shaped molecular aggregates (as depicted in Figs. 2 and 3), which are close-packed in the solid state, again mediated by a number of weak C—H O hydrogen bonds, leading to the observed crystal structure of the title compound (Fig. 3).
Experimental
Ethyl [3-(2-pyridyl)pyrazol-1-yl]acetate was prepared following the synthetic procedure described by Thielet al.(1994). Suitable single crystals were isolated by the slow diffusion at 277 K of hexane into a solution of the compound in ethyl acetate.
organic papers
Acta Cryst.(2007). E63, o1380–o1382 Coelhoet al. C
[image:2.610.106.477.73.185.2]12H13N3O2H2O
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Figure 1
The asymmetric unit of the title compound, emphasizing the structural differences associated with the terminal —CH2—CH3groups. Displacement
[image:2.610.125.507.226.417.2] [image:2.610.46.295.460.631.2]ellipsoids are drawn at the 50% probability level. Both disorder components are shown.
Figure 2
Interconnections (dashed lines) between the organic and water molecules of (I). Water H atoms have been omitted. [Symmetry codes: (i)x, 1 +y,z; (ii)
x, 1y, 1z.]
Figure 3
Crystal data
C12H13N3O2H2O Mr= 249.27 Monoclinic, P21=n a= 22.332 (2) A˚
b= 4.7356 (5) A˚
c= 24.651 (3) A˚
= 104.929 (6)
V= 2519.0 (5) A˚3
Z= 8
MoKradiation
= 0.10 mm1 T= 100 (2) K 0.400.160.08 mm
Data collection
Bruker X8 APEXII diffractometer Absorption correction: multi-scan
(SADABS; Sheldrick, 1998)
Tmin= 0.927,Tmax= 0.985
27588 measured reflections 4387 independent reflections 3182 reflections withI> 2(I)
Rint= 0.030
Refinement
R[F2> 2(F2)] = 0.061 wR(F2) = 0.176
S= 1.02 4387 reflections 345 parameters
H atoms treated by a mixture of independent and constrained refinement
max= 0.95 e A˚3 min=0.77 e A˚
3
Table 1
Hydrogen-bond geometry (A˚ ,).
D—H A D—H H A D A D—H A
O1W—H1A N1i
1.00 (1) 1.91 (2) 2.900 (3) 168 (3) O1W—H1B O1Wii 1.00 (1) 1.98 (3) 2.762 (5) 133 (4) O1W—H1C O1Wiii
1.00 (1) 1.80 (2) 2.743 (5) 157 (4) O2W—H2A N4 1.00 (1) 1.95 (2) 2.926 (3) 166 (3) O2W—H2B O2Wiv
1.00 (1) 1.81 (3) 2.729 (5) 152 (4) O2W—H2C O2Wv
1.00 (1) 1.83 (2) 2.757 (5) 153 (5) C8—H8 O3v
0.95 2.44 3.219 (3) 140 C9—H9A O1i
0.99 2.54 3.252 (3) 129 C19—H19 O2W 0.95 2.49 3.351 (4) 151 C20—H20 O1vi
0.95 2.38 3.181 (3) 141
Symmetry codes: (i) x;yþ1;z; (ii) x;yþ1;z; (iii) x;yþ2;z; (iv) x;yþ2;zþ1; (v)x;yþ1;zþ1; (vi)x;y;zþ1.
The pseudo-translation symmetry of this structure was clear from an initial structure solution attempt in a unit cell of half the volume, requiring substantial disorder modelling, followed by examination of data from longer exposures, which indicated the doubling of theaaxis length to give the result reported here. Even with long exposures and a low-temperature data collection, the crystal diffracted quite weakly at high angle.
The two crystallographically independent terminal —CH2—CH3
groups are probably disordered, particularly for C23 and C24, but this could not be resolved. The C23—C24 distance was restrained to 1.47 (1) A˚ in the final refinement. The main difference map features lie close to these atoms.
H atoms bound to carbon were placed in idealized positions, with C—H = 0.95–0.99 A˚ , and refined using a riding model, withUiso(H) =
1.2 (aromatic and CH2) or 1.5 (CH3) timesUeq(C). Water H atoms
were visible in difference Fourier maps, including the twofold disorder of one H atom for each molecule (that involved in the O—
H O hydrogen bonds with symmetry-related water molecules). O—
H and H H distances were restrained to 1.00 (1) and 1.66 (1) A˚ , respectively, and the disordered H atoms were assigned an occupancy of 0.5.
Data collection:APEX2(Bruker, 2006); cell refinement:APEX2;
data reduction:SAINT-Plus(Bruker, 2005); program(s) used to solve
structure: SHELXTL (Bruker 2001); program(s) used to refine
structure: SHELXTL; molecular graphics: DIAMOND
(Branden-burg, 2006); software used to prepare material for publication:
SHELXTL.
The authors are grateful to Fundac¸a˜o para a Cieˆncia e Tecnologia (FCT, Portugal) for financial support (POCI/CTM/ 58863/2004) and also for funding towards the purchase of the diffractometer.
References
Bernstein, J., Davis, R. E., Shimoni, L. & Chang, N.-L. (1995).Angew. Chem. Int. Ed. Engl.34, 1555–1573.
Brandenburg, K. (2006).DIAMOND. Version 3.1d. Crystal Impact GbR, Bonn, Germany.
Bruker (2001). SHELXTL. Version 6.12. Bruker AXS Inc., Madison, Wisconsin, USA.
Bruker (2005). SAINT-Plus. Version 7.23a. Bruker AXS Inc., Madison, Wisconsin, USA.
Bruker (2006).APEX2. Version 2.1-RC13. Bruker Nonius BV, Delft, The Netherlands.
Bruno, S. M., Fernandes, J. A., Martins, L. S., Gonc¸alves, I. S., Pillinger, M., Ribeiro-Claro, P., Rocha, J. & Valente, A. A. (2006).Catal. Today,114, 263– 271.
Bruno, S. M., Pereira, C. C. L., Balula, M. S., Nolasco, M., Valente, A. A., Hazell, A., Pillinger, M., Ribeiro-Claro, P. & Gonc¸alves, I. S. (2007).J. Mol. Catal. A Chem.261, 79–87.
Coelho, A. C., Almeida Paz, F. A., Klinowski, J., Pillinger, M. & Gonc¸alves, I. S. (2006).Molecules, 11, 940–952.
Gago, S., Fernandes, J. A., Abrantes, M., Ku¨hn, F. E., Ribeiro-Claro, P., Pillinger, M., Santos, T. M. & Gonc¸alves, I. S. (2006). Microporous Mesoporous Mater.89, 284–290.
Gago, S., Fernandes, J. A., Rainho, J. P., Sa´ Ferreira, R. A., Pillinger, M., Valente, A. A., Santos, T. M., Carlos, L. D., Ribeiro-Claro, P. & Gonc¸alves, I. S. (2005).Chem. Mater.17, 5077–5084.
Sheldrick, G. M. (1998).SADABS. Version 2.01. Bruker AXS Inc., Madison, Wisconsin, USA.
Thiel, W. R., Angstl, M. & Priermeier, T. (1994). Chem. Ber.127, 2373– 2379.
organic papers
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Coelhoet al. Csupporting information
sup-1 Acta Cryst. (2007). E63, o1380–o1382
supporting information
Acta Cryst. (2007). E63, o1380–o1382 [https://doi.org/10.1107/S1600536807007015]
Ethyl [3-(2-pyridyl)pyrazol-1-yl]acetate monohydrate
Ana C. Coelho, Isabel S. Gon
ç
alves and Filipe A. Almeida Paz
Ethyl [3-(2-pyridyl)pyrazol-1-yl]acetate monohydrate
Crystal data
C12H13N3O2·H2O
Mr = 249.27 Monoclinic, P21/n Hall symbol: -P 2yn
a = 22.332 (2) Å
b = 4.7356 (5) Å
c = 24.651 (3) Å
β = 104.929 (6)°
V = 2519.0 (5) Å3
Z = 8
F(000) = 1056
Dx = 1.315 Mg m−3
Mo Kα radiation, λ = 0.71073 Å Cell parameters from 9034 reflections
θ = 2.9–30.1°
µ = 0.10 mm−1
T = 100 K Needle, colourless 0.40 × 0.16 × 0.08 mm
Data collection
Bruker X8 APEXII diffractometer
Radiation source: fine-focus sealed tube Graphite monochromator
ω and φ scans
Absorption correction: multi-scan (SADABS; Sheldrick, 1998)
Tmin = 0.927, Tmax = 0.985
27588 measured reflections 4387 independent reflections 3182 reflections with I > 2σ(I)
Rint = 0.030
θmax = 25.4°, θmin = 3.7°
h = −26→26
k = −5→5
l = −28→27
Refinement
Refinement on F2 Least-squares matrix: full
R[F2 > 2σ(F2)] = 0.061
wR(F2) = 0.176
S = 1.02 4387 reflections 345 parameters 13 restraints
Primary atom site location: structure-invariant direct methods
Secondary atom site location: difference Fourier map
Hydrogen site location: inferred from neighbouring sites
H atoms treated by a mixture of independent and constrained refinement
w = 1/[σ2(F
o2) + (0.0711P)2 + 4.6214P] where P = (Fo2 + 2Fc2)/3
(Δ/σ)max = 0.003 Δρmax = 0.95 e Å−3 Δρmin = −0.77 e Å−3
Special details
supporting information
sup-2 Acta Cryst. (2007). E63, o1380–o1382
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)
x y z Uiso*/Ueq Occ. (<1)
N1 0.14974 (10) −0.1946 (5) 0.09385 (10) 0.0260 (6) N2 0.14440 (9) 0.2986 (5) 0.20435 (9) 0.0202 (5) N3 0.09557 (10) 0.4700 (5) 0.20315 (9) 0.0216 (5) O1 0.05648 (9) 0.2543 (4) 0.29203 (8) 0.0305 (5) O2 0.10854 (8) 0.5945 (4) 0.34809 (8) 0.0261 (5) C1 0.18800 (13) −0.3854 (7) 0.08040 (13) 0.0323 (7)
H1 0.1741 −0.4824 0.0457 0.039*
C2 0.24594 (13) −0.4496 (6) 0.11357 (13) 0.0304 (7)
H2 0.2713 −0.5860 0.1020 0.037*
C3 0.26606 (12) −0.3103 (6) 0.16403 (12) 0.0256 (7)
H3 0.3057 −0.3498 0.1882 0.031*
C4 0.22787 (11) −0.1124 (6) 0.17904 (11) 0.0217 (6)
H4 0.2410 −0.0135 0.2136 0.026*
C5 0.17003 (11) −0.0597 (6) 0.14304 (11) 0.0192 (6) C6 0.12735 (11) 0.1496 (6) 0.15679 (11) 0.0198 (6) C7 0.06734 (12) 0.2240 (6) 0.12577 (12) 0.0267 (6)
H7 0.0447 0.1492 0.0907 0.032*
C8 0.04862 (12) 0.4279 (6) 0.15721 (12) 0.0272 (7)
H8 0.0097 0.5220 0.1483 0.033*
C9 0.09717 (12) 0.6474 (6) 0.25111 (11) 0.0226 (6)
H9A 0.0656 0.7982 0.2404 0.027*
H9B 0.1384 0.7379 0.2638 0.027*
C10 0.08445 (11) 0.4738 (6) 0.29833 (11) 0.0221 (6) C11 0.09967 (14) 0.4351 (7) 0.39598 (12) 0.0317 (7)
H11A 0.1185 0.2454 0.3969 0.038*
H11B 0.0549 0.4116 0.3930 0.038*
C12 0.1295 (2) 0.5929 (11) 0.44772 (15) 0.0821 (17)
H12A 0.1744 0.5990 0.4522 0.123*
H12B 0.1208 0.4984 0.4802 0.123*
H12C 0.1131 0.7858 0.4450 0.123*
N4 0.13995 (10) 0.7214 (5) 0.59836 (10) 0.0244 (5) N5 0.14357 (9) 0.2208 (5) 0.70981 (9) 0.0199 (5) N6 0.09557 (10) 0.0492 (4) 0.71125 (9) 0.0205 (5) O3 0.05836 (10) 0.2304 (5) 0.80469 (10) 0.0387 (6) O4 0.11124 (10) −0.1265 (6) 0.85499 (9) 0.0473 (7) C13 0.17597 (13) 0.9154 (6) 0.58258 (12) 0.0277 (7)
H13 0.1590 1.0183 0.5491 0.033*
C14 0.23591 (13) 0.9747 (6) 0.61188 (12) 0.0266 (6)
H14 0.2599 1.1112 0.5986 0.032*
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sup-3 Acta Cryst. (2007). E63, o1380–o1382
H15 0.3011 0.8659 0.6828 0.030*
C16 0.22401 (11) 0.6307 (6) 0.67883 (12) 0.0218 (6)
H16 0.2399 0.5289 0.7127 0.026*
C17 0.16401 (11) 0.5816 (5) 0.64625 (11) 0.0191 (6) C18 0.12330 (11) 0.3721 (5) 0.66278 (11) 0.0187 (6) C19 0.06234 (12) 0.2962 (6) 0.63481 (12) 0.0261 (6)
H19 0.0377 0.3711 0.6006 0.031*
C20 0.04619 (12) 0.0914 (6) 0.66742 (12) 0.0254 (6)
H20 0.0074 −0.0032 0.6605 0.031*
C21 0.10115 (13) −0.1367 (6) 0.75851 (11) 0.0242 (6)
H21A 0.1437 −0.2143 0.7698 0.029*
H21B 0.0720 −0.2967 0.7474 0.029*
C22 0.08733 (12) 0.0156 (6) 0.80798 (13) 0.0274 (7) C23 0.09520 (17) −0.0295 (14) 0.90468 (15) 0.103 (2)
H23A 0.0731 −0.1814 0.9192 0.123*
H23B 0.0670 0.1346 0.8952 0.123*
C24 0.1508 (2) 0.0518 (15) 0.94815 (18) 0.114 (3)
H24A 0.1852 −0.0729 0.9463 0.171*
H24B 0.1425 0.0352 0.9852 0.171*
H24C 0.1617 0.2475 0.9420 0.171*
O1W 0.03239 (11) 0.7511 (5) 0.01011 (10) 0.0507 (7) H1A 0.0699 (9) 0.761 (7) 0.0427 (8) 0.076*
H1B −0.0006 (11) 0.626 (8) 0.0178 (15) 0.076* 0.50 H1C 0.0162 (15) 0.942 (3) −0.0035 (17) 0.076* 0.50 O2W 0.01234 (11) 0.7517 (5) 0.52880 (10) 0.0514 (7)
H2A 0.0571 (4) 0.768 (7) 0.5492 (13) 0.077*
H2B −0.0065 (15) 0.939 (3) 0.515 (2) 0.077* 0.50 H2C 0.0049 (16) 0.607 (8) 0.4983 (15) 0.077* 0.50
Atomic displacement parameters (Å2)
U11 U22 U33 U12 U13 U23
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sup-4 Acta Cryst. (2007). E63, o1380–o1382
C12 0.124 (4) 0.094 (4) 0.028 (2) −0.069 (3) 0.020 (2) −0.006 (2) N4 0.0244 (12) 0.0214 (12) 0.0264 (13) −0.0028 (9) 0.0049 (10) −0.0017 (10) N5 0.0166 (11) 0.0182 (11) 0.0266 (13) −0.0004 (9) 0.0087 (10) −0.0016 (9) N6 0.0186 (11) 0.0170 (12) 0.0272 (13) 0.0004 (9) 0.0080 (10) −0.0007 (9) O3 0.0345 (12) 0.0357 (13) 0.0519 (14) 0.0062 (10) 0.0221 (11) −0.0107 (11) O4 0.0374 (13) 0.0805 (19) 0.0242 (12) 0.0218 (12) 0.0086 (10) −0.0043 (12) C13 0.0355 (16) 0.0238 (15) 0.0236 (15) −0.0034 (12) 0.0071 (13) −0.0008 (12) C14 0.0289 (15) 0.0217 (15) 0.0333 (17) −0.0066 (11) 0.0156 (13) −0.0043 (12) C15 0.0182 (13) 0.0219 (15) 0.0343 (17) −0.0017 (11) 0.0079 (12) −0.0070 (12) C16 0.0171 (13) 0.0216 (14) 0.0263 (16) 0.0028 (10) 0.0046 (12) −0.0031 (11) C17 0.0192 (13) 0.0166 (13) 0.0224 (15) 0.0010 (10) 0.0071 (12) −0.0050 (11) C18 0.0168 (13) 0.0158 (13) 0.0240 (15) 0.0014 (10) 0.0063 (11) −0.0030 (11) C19 0.0197 (14) 0.0254 (15) 0.0308 (16) −0.0021 (11) 0.0025 (12) 0.0016 (12) C20 0.0159 (13) 0.0259 (15) 0.0326 (17) −0.0031 (11) 0.0029 (13) −0.0012 (12) C21 0.0259 (14) 0.0193 (14) 0.0299 (16) 0.0003 (11) 0.0116 (13) −0.0001 (11) C22 0.0194 (14) 0.0311 (17) 0.0342 (17) −0.0028 (12) 0.0116 (13) −0.0065 (13) C23 0.071 (3) 0.207 (7) 0.029 (2) 0.065 (4) 0.010 (2) −0.026 (3) C24 0.104 (4) 0.189 (7) 0.069 (3) −0.085 (4) 0.058 (3) −0.075 (4) O1W 0.0407 (13) 0.0485 (15) 0.0482 (15) 0.0002 (11) −0.0149 (12) −0.0008 (12) O2W 0.0410 (14) 0.0463 (15) 0.0530 (16) −0.0080 (11) −0.0132 (12) 0.0070 (12)
Geometric parameters (Å, º)
N1—C5 1.342 (3) N5—N6 1.353 (3)
N1—C1 1.343 (3) N6—C20 1.345 (3)
N2—C6 1.337 (3) N6—C21 1.440 (3)
N2—N3 1.354 (3) O3—C22 1.197 (3)
N3—C8 1.345 (4) O4—C22 1.327 (4)
N3—C9 1.443 (3) O4—C23 1.437 (4)
O1—C10 1.202 (3) C13—C14 1.376 (4)
O2—C10 1.334 (3) C13—H13 0.950
O2—C11 1.457 (3) C14—C15 1.380 (4)
C1—C2 1.375 (4) C14—H14 0.950
C1—H1 0.950 C15—C16 1.379 (4)
C2—C3 1.377 (4) C15—H15 0.950
C2—H2 0.950 C16—C17 1.393 (4)
C3—C4 1.380 (4) C16—H16 0.950
C3—H3 0.950 C17—C18 1.472 (4)
C4—C5 1.388 (4) C18—C19 1.405 (4)
C4—H4 0.950 C19—C20 1.366 (4)
C5—C6 1.474 (3) C19—H19 0.950
C6—C7 1.406 (4) C20—H20 0.950
C7—C8 1.369 (4) C21—C22 1.515 (4)
C7—H7 0.950 C21—H21A 0.990
C8—H8 0.950 C21—H21B 0.990
C9—C10 1.511 (4) C23—C24 1.467 (6)
C9—H9A 0.990 C23—H23A 0.990
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sup-5 Acta Cryst. (2007). E63, o1380–o1382
C11—C12 1.481 (5) C24—H24A 0.980
C11—H11A 0.990 C24—H24B 0.980
C11—H11B 0.990 C24—H24C 0.980
C12—H12A 0.980 O1W—H1A 1.00 (1)
C12—H12B 0.980 O1W—H1B 1.00 (1)
C12—H12C 0.980 O1W—H1C 1.00 (1)
N4—C17 1.339 (3) O2W—H2A 1.00 (1)
N4—C13 1.343 (3) O2W—H2B 1.00 (1)
N5—C18 1.339 (3) O2W—H2C 1.00 (1)
C5—N1—C1 117.1 (2) C20—N6—C21 128.5 (2)
C6—N2—N3 104.6 (2) N5—N6—C21 119.0 (2)
C8—N3—N2 112.2 (2) C22—O4—C23 116.7 (3)
C8—N3—C9 128.7 (2) N4—C13—C14 124.2 (3)
N2—N3—C9 118.8 (2) N4—C13—H13 117.9
C10—O2—C11 114.6 (2) C14—C13—H13 117.9
N1—C1—C2 124.3 (3) C13—C14—C15 117.8 (3)
N1—C1—H1 117.9 C13—C14—H14 121.1
C2—C1—H1 117.9 C15—C14—H14 121.1
C1—C2—C3 118.0 (3) C16—C15—C14 119.4 (3)
C1—C2—H2 121.0 C16—C15—H15 120.3
C3—C2—H2 121.0 C14—C15—H15 120.3
C2—C3—C4 119.2 (3) C15—C16—C17 119.0 (3)
C2—C3—H3 120.4 C15—C16—H16 120.5
C4—C3—H3 120.4 C17—C16—H16 120.5
C3—C4—C5 119.2 (3) N4—C17—C16 122.2 (2)
C3—C4—H4 120.4 N4—C17—C18 116.2 (2)
C5—C4—H4 120.4 C16—C17—C18 121.6 (2)
N1—C5—C4 122.3 (2) N5—C18—C19 110.9 (2)
N1—C5—C6 116.1 (2) N5—C18—C17 120.3 (2)
C4—C5—C6 121.6 (2) C19—C18—C17 128.8 (2)
N2—C6—C7 111.2 (2) C20—C19—C18 105.2 (2)
N2—C6—C5 120.1 (2) C20—C19—H19 127.4
C7—C6—C5 128.7 (2) C18—C19—H19 127.4
C8—C7—C6 104.8 (2) N6—C20—C19 107.0 (2)
C8—C7—H7 127.6 N6—C20—H20 126.5
C6—C7—H7 127.6 C19—C20—H20 126.5
N3—C8—C7 107.2 (2) N6—C21—C22 111.5 (2)
N3—C8—H8 126.4 N6—C21—H21A 109.3
C7—C8—H8 126.4 C22—C21—H21A 109.3
N3—C9—C10 110.2 (2) N6—C21—H21B 109.3
N3—C9—H9A 109.6 C22—C21—H21B 109.3
C10—C9—H9A 109.6 H21A—C21—H21B 108.0
N3—C9—H9B 109.6 O3—C22—O4 125.4 (3)
C10—C9—H9B 109.6 O3—C22—C21 124.6 (3)
H9A—C9—H9B 108.1 O4—C22—C21 110.0 (2)
O1—C10—O2 124.2 (3) O4—C23—C24 110.9 (3)
supporting information
sup-6 Acta Cryst. (2007). E63, o1380–o1382
O2—C10—C9 111.3 (2) C24—C23—H23A 109.5
O2—C11—C12 108.1 (3) O4—C23—H23B 109.5
O2—C11—H11A 110.1 C24—C23—H23B 109.5
C12—C11—H11A 110.1 H23A—C23—H23B 108.0
O2—C11—H11B 110.1 C23—C24—H24A 109.5
C12—C11—H11B 110.1 C23—C24—H24B 109.5
H11A—C11—H11B 108.4 H24A—C24—H24B 109.5
C11—C12—H12A 109.5 C23—C24—H24C 109.5
C11—C12—H12B 109.5 H24A—C24—H24C 109.5
H12A—C12—H12B 109.5 H24B—C24—H24C 109.5
C11—C12—H12C 109.5 H1A—O1W—H1B 112.39 (17)
H12A—C12—H12C 109.5 H1A—O1W—H1C 112.40 (17) H12B—C12—H12C 109.5 H1B—O1W—H1C 112.39 (17) C17—N4—C13 117.3 (2) H2A—O2W—H2B 112.39 (17) C18—N5—N6 104.5 (2) H2A—O2W—H2C 112.38 (17) C20—N6—N5 112.4 (2) H2B—O2W—H2C 112.38 (17)
supporting information
sup-7 Acta Cryst. (2007). E63, o1380–o1382
Hydrogen-bond geometry (Å, º)
D—H···A D—H H···A D···A D—H···A
O1W—H1A···N1i 1.00 (1) 1.91 (2) 2.900 (3) 168 (3) O1W—H1B···O1Wii 1.00 (1) 1.98 (3) 2.762 (5) 133 (4) O1W—H1C···O1Wiii 1.00 (1) 1.80 (2) 2.743 (5) 157 (4) O2W—H2A···N4 1.00 (1) 1.95 (2) 2.926 (3) 166 (3) O2W—H2B···O2Wiv 1.00 (1) 1.81 (3) 2.729 (5) 152 (4) O2W—H2C···O2Wv 1.00 (1) 1.83 (2) 2.757 (5) 153 (5)
C8—H8···O3v 0.95 2.44 3.219 (3) 140
C9—H9A···O1i 0.99 2.54 3.252 (3) 129
C19—H19···O2W 0.95 2.49 3.351 (4) 151
C20—H20···O1vi 0.95 2.38 3.181 (3) 141