Original Article Regulation and mechanisms of lncRNA H19 in COPD

DNA methylation of the lncRNA-H19 promoter was lower in unexplained miscarriage samples than in normal pregnancy samples, leading to lncRNA-H19 upregulation in placental villi from

Overexpression of miR-124 up-regulated apoptosis-associated Bcl-2 expression (P<0.05), inhibited expression of activated caspase-3 (P<0.05), and enhanced proliferation

The following western blotting results indicated that FCL down-regulated the expression of Bcl-2, caspase 3, up- regulated the expression of Bax, cleaved caspase 3 and stimulated

Expression of Bcl-2 in group C was sig- nificantly higher than that in group B, suggest - ing that Pueraria isoflavones effectively inhibit expression of Caspase-3 and Bax proteins in

After the administration of fasudil, the thickness of the intima and media decreased, the expression of ROCK mRNA and Bcl-2 decreased in VSMCs, whereas the expression of

Down-regulating DANCR inhibited the malignant proliferation of BC cells and also promoted apoptosis and autophagy, which showed that caspase-3, caspase-9, Bax/ Bcl-2, LC3B,

Transfection with shLncRNA H19-2 significantly decreased the proliferation, migration, and invasion of A549 cells, while overexpression of LncRNA H19 had the opposite effect in

As shown in Figure 3, forbesione combined with 5-FU significantly decreased the expression level of Bcl-2 and procaspase-3, whereas the expression of Bax, activated caspase-9