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Glutaminase and poly(ADP ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL deficient renal cancers

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Figure

Figure 1. multiple comparisons) compared “unlabeled” fraction of aspartate. (Biosynthesis of DNA pyrimidines from glutamine carbons in RCC cells
Figure 2. VHL[U-was measured by LC-MS/MS. Effect of BPTES on the Inhibition of GLS1 decreases intracellular aspartate and selectively suppresses de novo pyrimidine synthesis in VHL–/– cells
Figure 3. Inhibition of GLS1 selectively increases intracel-
Figure 4. Isogenic pairs of nett’s test against corresponding control conditions (Inhibition of GLS1 selectively impairs the growth of VHL–/– RCC cells, and exogenous metabolites rescue the growth inhibition effects
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