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Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism

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Figure

Figure 1 PHDs are 2OG-dependent dioxygenases that regulate the stability of HiFα. in the presence of oxygen, PHDs post-translationally hydroxylate a prolyl residue in the NODDD and CODDD of HiFα subunits, which leads to its interaction with pvHL and ubiqui
Figure 2 HiF-dependent regulation of metabolism. Note: HIF1 promotes anaerobic metabolism by upregulating, glycolytic enzymes and glucose transporters to increase flux through the glycolytic pathway; LDHA and MCT4 to facilitate lactate secretion; PDK1 and
Table 1 Phenotypes of Phd-deficient mice
Table 1 (Continued)
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