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A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles

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Academic year: 2020

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Figure 2 Schematic diagram of the PBPK model structures for (A) ionic and (B) nanoparticulate silver, which were used both for rats and humans.Note: In the ionic silver model no transport of silver from the brain to the blood was modeled, to consider the blood–brain barrier.Abbreviations: MPS, mononuclear phagocyte system; PBPK, physiologically based pharmacokinetic.
Figure 3 Metabolism of ionic silver and nanosilver and the connection between the PBPK models
Figure 4 Comparison of the PBPK model simulations to toxicokinetic data of rats after oral exposure for 28 days.acetatesilver; *intestinal absorption fractions were fitted to match blood silver levels (listed in Table S7); °transformation of soluble silver
Figure 5 Comparison of the PBPK models to toxicokinetic data of rats after inhalation or instillation of silver.particles.were fitted to match blood/liver silver levels (listed in Table S8), pulmonary clearance fractions were calibrated to match lung silve
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