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Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination

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Figure

Figure 1. Identification of a key region in the DNA-PKcs promoter. A, E. coli HIV-1 Tat protein was added into the culture medium of MT2 cells, and DNA-PKcs was constructs were transfected into HEK293 cells to determine their promoter activity
Figure 2. HIV-1 Tat down-regulates DNA-PKcs at the transcriptional level. A, The firefly luciferase reporter plasmid pGL3-basic containing the full-length DNA-PKcs cells and recombinant Tat protein was added 24 h after the transfection
Figure 3. Direct interaction between Tat and DNA-PKcs. A, MT2 cells were transfected with a myc-Tat plasmid
Figure 4. HIV-1 Tat activates DNA-PKcs in a DNA-independent manner. A, DNA-PKcs S2056 phosphorylation in TE671, TE671-Tat (stably expressing Tat), MT2 and recombinant-Tat-treated MT2 cells was assayed with anti-S2056-p WB analysis
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