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Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

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Figure

Table 1 Effect of SG2000 on the growth of canine cancer cellsand canine normal cells following a 1 h or continuous (96 h)exposure
Fig. 1 Measurement of DNA interstrand cross-linking using the single cell gel electrophoresis (comet) assay.SG2000-induced DNA ICLs in the canine melanoma cell line CMeC-1 following a 1 h treatment with SG2000 at 53 nM during 48 h ofpost-incubation in drug
Fig. 2 SG2000-induced cell cycle alterations in four canine melanoma cell lines following a 1 h treatment with equitoxic (GI50) doses of SG2000and 72 h of post-incubation
Fig. 3 a. Immunofluorescence detection of γH2AX phosphorylation in the canine melanoma CMeC-1 cell line following a 1 h treatment with 10nM SG2000 and up to 48 h of post-incubation in drug-free medium
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