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<p>Dapagliflozin Activates Neurons in the Central Nervous System and Regulates Cardiovascular Activity by Inhibiting SGLT-2 in Mice</p>

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Table 2 Changes in Diastolic BP in Control Group vs SGLT-2iTreatment Group
Table 3 The Change of HR in Control Group vs SGLT-2iTreatment Group
Figure 2 Grayscale contrast showing expression of SGLT-2 in Telencephalon (A and B); Diencephalon (C and D); Midbrain and Brainstem (E and F).Abbreviations: AOM, medial anterior olfactory region; AOL, anterior olfactory nucleus, lateral part; AOD, anterior olfactory nucleus, dorsal part; AOVP, anterior olfactory nucleus,ventroposterior part; DTT, dorsal tenia tecta layer; E/OV, olfactory ventricle (olfactory part of lateral ventricle); AOP, anterior olfactory nucleus, posterior part; aca, anteriorcommissure, anterior part; PrL, prelimbic cortex; fmi, forceps minor of the corpus callosum; CPu, caudate putamen (striatum); Nv, navicular nucleus of the basal forebrain; DTT, dorsaltenia tecta; DP, dorsal peduncular cortex; Cg2, cingulate cortex, area 2; LSI, lateral septal nucleus, intermediate part; LSV, lateral septal nucleus, ventral part; LSD, lateral septal nucleus,dorsal part; VDB, nucleus of the vertical limb of the diagonal band; CC, corpus callosum; LSD, lateral septal nucleus, dorsal part; MnPO, median preoptic nucleus; BNST, bed nucleus ofthe stria terminalis; ac, anterior commissure; LPO, lateral preoptic area; MPA, medial preoptic area; MPO, medial preoptic nucleus; PVA, paraventricular thalamic nucleus, anterior part;PVN, paraventricular hypothalamic nucleus; CM, central medial thalamic nucleus; AM, anteromedial thalamic nucleus; Re, reuniens thalamic nucleus; LH, lateral hypothalamus; RCh,retrochiasmatic area; CA3, field CA3 of the hippocampus; PVA, paraventricular thalamic nucleus, anterior part; PVP, paraventricular thalamic nucleus, posterior part; PV, paraventricularthalamic nucleus; IAM, interanteromedial thalamic nucleus; Re, reuniens thalamus nucleus; PH, posterior hypothalamic nucleus; AHC, anterior hypothalamic area, central part; DMD,dorsomedial hypothalamic nucleus, dorsal part; DM, dorsomedial hypothalamic nucleus; VMH, ventromedial hypothalamic nucleus; VMHVL, ventromedial hypothalamic nucleus,ventrolateral part; Arc, arcuate hypothalamic nucleus; ME, median eminence; ML, medial mammillary nucleus, lateral part; VTM, ventral tuberomammillary nucleus; p1PAG, p1periaqueductal gray; PrC, precommissural nucleus; PAG, periaqueductal gray; Aq, aqueduct; Pn, pontine nuclei; DCIC, dorsal cortex of the inferior colliculus; DLL, dorsal nucleus of thelateral leminiscus; DRD, dorsal raphe nucleus, dorsal part; PTg, pedunculopontine tegmental nucleus; LPB, lateral parabrachial nucleus; DTgP, dorsal tegmental nucleus, pericentral part;DTgC, dorsal tegmental nucleus, central part; CG, central gray; LC, locus coerules; PDTg, posterodorsal tgmental nucleus; PO, periolivary nucleus; py, pyramidal tract; 4V, 4th ventricle;solitary tract nucleus; Rt, reticular nucleus; AP, area postrema.
Table 4 Quantitative Measure of Fos-Immunoreactivity inControl Group vs SGLT-2i Treatment Group
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