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Paget’s disease of bone: an osteoimmunological disorder?

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Figure

Figure 1 Main osteoimmunological cell differentiations and cell lineages.Abbreviation: NK cell, natural killer cell.
Figure 2 Pathophysiology of Paget’s disease of bone and its relation to osteoimmunological cells and cytokines.Abbreviations: RANKL, Receptor Activator of Nuclear factor Kappa-B Ligand; TNF, Tumor Necrosis Factor-α; iFN, interferon; MAPK, mitogen-activated protein kinase.
Table 3 Overview of the main clinical trials or case reports in which a cytokine or its receptor, involved in osteoimmunological process related to a rheumatic or musculoskeletal disorder, was targeted

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