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Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells

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Figure 1: Eupafolin sensitizes TRAIL-induced apoptosis in Caki cells. A-C. Caki cells were treated with 50 ng/ml TRAIL in the presence or absence of the indicated concentrations with eupafolin for 24 h (A) or indicated time periods (B and C)
Figure 2: Effects of eupafolin on expression levels of apoptosis-related proteins. Caki cells were treated with the indicated concentrations of eupafolin for 24 h
Figure 3: Eupafolin induced cathepsin S-mediated down-regulation of Mcl-1 expression. A
Figure 4: Eupafolin induces up-regulation of Bim expression through AMPK-mediated inhibition of proteasome activity
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