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Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α- ATF4-xCT pathway

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Figure

Figure 1: Cisplatin-resistant gastric cancer cells have high xCT expression and rely on environmental cystine for cell survival
Figure 2: Inhibition and knockdown of xCT increase the cisplatin sensitivity of cisplatin-resistant gastric cancer cells, and high xCT expression is a poor prognostic factor in gastric cancer patients under adjuvant chemotherapy treatment
Figure 3: Mitochondrial dysfunction enhances cisplatin resistance and increases xCT expression in human gastric cancer cells
Figure 4: Inhibition and knockdown of xCT reduce mitochondrial dysfunction-enhanced cisplatin resistance
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