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Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity

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Figure

Fig. 1 The interaction model can accurately attribute eQTLs to cancer using bulk tumor gene expression in simulated data
Fig. 3a) using the conventional model. However, using the
Fig. 3 Using the interaction model to identify cancer eQTL profiles from TCGA breast bulk tumor gene expression data.fibroblasts from GTEx
Fig. 4 Classification and annotations for eQTLs identified using agenes whose eQTL profile changes between TCGA breast cancerdata ((bulk tumor) or interaction (cancer) model that are likely to be derivedfrom normal cells, based on3679 GO biological process
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