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Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe

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Figure

Figure 1: Loss of Aurora kinases disrupts PLK1 activity during mitosis. (A) Depletion of AURKA impairs the activation of PLK1
Figure 2: Inhibition of PLK1 with BI 2536 induces metaphase defects and mitotic catastrophe
Figure 3: PLK1i cooperates with Aurora kinase inhibitors to induce mitotic catastrophe
Figure 4: PLK1i cooperates with Aurora kinase inhibitors to induce mitotic arrest and slippage
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