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Enhancing full-length antibody production by signal peptide engineering

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Figure

Table 1 The amino acid sequences of  the signal peptide TIR variants
Table 2 The processing of  hu5D5 heavy chain mediated by  ssSTII, ssDsbA, ssPhoA, and  ssMalE at  a relative TIR strength of one
Fig. 2 The amino acid sequences of signal peptides and the hydrophobicity of the H-region
Fig. 3 The effects of signal peptide hydrophobicity on full-length hu5D5 production. For all the constructs, light chain was fused to ssSTII0.3 and heavy chain was fused to ssSTII1, ssDsbA1, ssPhoA1, ssMalE1, ssSTII1 S-13L, ssSTII1 S-13I, ssDsbA1 L-9S, or
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