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Protein dynamics and conformational selection in bidirectional signal transduction

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Figure

Figure 1. The protein free energy landscape can describe the populations of all protein conformational substates
Figure 2. Initially, the binding of Eph-ephrin forms a dimeric structure. Because both ephrins and Eph receptors have multiple binding sites, however, Eph-ephrin binding may further form hetero-tetramer or higher oligomers if tighter cell-cell adhesion is

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