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The pupylation pathway and its role in mycobacteria

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Figure

Figure 1. Bacterial pupylation, like eukaryotic ubiquitination, targets proteins for proteasomal degradation
Figure 2. Occurrence, genomic organization and relatedness of the pupylation gene locus
Figure 3. The pupylation/depupylation cycle in mycobacteria. Dop (green) renders PupQ ligation-competent by deamidating the carboxy-terminal glutamine to glutamate
Figure 4. Dop and PafA are close structural homologs but catalyze distinct reactions. (a,b) The structures of Dop (a) and PafA (b) are shown in cartoon representation with ATP/ADP displayed in stick format

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