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Role of Long Non coding RNAs in Sculpting Neurons

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Academic year: 2020

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Figure

Fig. 1: Neuronal morphology varies according to function.(A) A motoneuron is typically multipolar whereas(B) invertebrates may have unipolar cells
Table 1: Summary of lncRNAs modulating neuronal architecture
Fig. 2: Schematic of Durga lncRNA action. Ectopic over-expression of Durga lncRNA by microinjection in onecell stage zebrafish embryos increase Kalirin RNAexpression at 24hpf and decrease dendritic densityand length in neuronal culture
Fig. 3: Schematic of proposed mechanisms of action oflncRNAs in dendritic spine. A) Control of RNA halflife by modulating its interactions with stability ordestability factors by lncRNA B) Scavenging ofmiRNAs by lncRNA to de-repress miRNA targets C)lncRNAs as a source of miRNAs D) lncRNAs as asource of small peptides E) Control of translation bymodulating recruitment of ribosomes on RNA F)Transport of factors in and out of the dendrites bylncRNAs

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