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Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence

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Figure

Fig. 1 Random mitochondrial point mutations in-vitro. There was a significantly increased frequency of random mitochondrial DNA mutations inthe QH cells (mean 7.710 × 10−5, SD 2.770 × 10−5) (n = 5) compared to HET1A (mean 2.560 × 10−5, SD 1.015 × 10−5) (n
Fig. 2 Random mitochondrial point deletions in-vivo. Wilcoxon matched-paired signed rank tests demonstrated a significantly increased level ofdeletions in the SIM matched normal tissue compared with SIM (p = 0.031) and a trend towards increased deletions i
Fig. 4 Expression of CYGB along the Barrettexpression of CYGB is demonstrated in normal (mean 0.425, standarderror of mean [SEM] 0.231), SIM (mean 11.013, SEM 8.493), LGD(mean 6.03, SEM 1.555), HGD (mean 3.580, SEM 1.580) and EACbiopsies (mean 4.581, SEM 0
Fig. 5 a-f Mitochondrial proteins and inflammatory cytokines levels in explant cultured media in SIM tissue and surrounding matched-normal tissue.Wilcoxon matched-pairs signed rank tests demonstrated significantly increased levels of a cytochrome c (n=12),

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