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Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway

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Figure

Fig. 1. pbltype siblings (right) stained under identical conditions (in head and dorsal closure defects
Fig. 2. Pbl acts to repress Wg pathway activity in embryos and cultured cells. (A,B) Normal Arm stripes were not altered by expression with (*control DNA
Fig. 3. Pbl requires GEF activity to regulate Wg signaling. (A) Protein domains of full-length and mutated forms of Pbl
Fig. 4. Pbl acts downstream of Arm stabilization. (A) of control GFP. By contrast, DROPflash to 26% of GFP control but was unable torepress destruction complex role
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