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A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation

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Academic year: 2020

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Figure

Fig. 1. Generating Elp1 conditional loss-of-functionmice.identified by PCR on genomic DNA template isolatedfrom tail biopsy tissue
Fig. 2. Conditional ablation of Elp1 in neural crest-derived cells (NCCs) results in death at birth and abnormal palatogenesis
Fig. 3. Loss of Elp1 in Wnt1-expressing neural crestcells does not alter the survival or migration of neuralcrest-derived SCG or DRG neurons
Fig. 5. Sympathetic target tissue innervation is impaired in Wnt1-Crehydroxylase (TH) immunohistochemistry showed target tissue innervationand visceral axon bundle branching abnormalities in newborn Wnt1-cKOcompared with+;Elp1f/f (Wnt1-cKO) mice
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