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A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice

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Academic year: 2020

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Figure

Figure 1: Dominant-negative expression of β-TrCP1/FWD1 disrupts NF-κB signaling in myeloma cells
Figure 2: Tumor burden is significantly reduced in disseminated myeloma mouse model bearing 5TGM1-∆F myeloma cells
Figure 3: ∆F mutant attenuates myeloma cell growth in a cell-autonomous mode. A subcutaneous plasmacytoma model, in which tumor cells were inoculated subcutaneously in flank of syngeneic naïve mice, was used to determine the role of the bone marrow microen
Figure 4: Bone marrow stromal cells do not protect 5TGM1-∆F myeloma cells from TNF-α-induced apoptosis
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