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The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft versus host disease

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Figure

Figure 1Clinical GVHD correlates with tGVHD and thymic function of B6 → BALB/c (8.5 Gy) mice
Figure 2Alloreactive T cells quickly infiltrate the thymus, undergo proliferation, and display an activated
Figure 3Alloreactive T cells require FasL and TRAIL to mediate tGVHD. (
Figure 4Soluble DR5 agonists are sufficient to damage the thymus after allo-BMT in 5
+4

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