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Toxicological Evaluation of Occidiofungin against Mice and Human Cancer Cell Lines

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Figure

Figure 1. Covalent structure of occidiofungin. Circles represent amino acid positions: Asn/β-hydroxy Asn1, Novel Amino Acid (NAA2), Ser3, β-hydroxy Tyr/chloro β-hydroxy Tyr4, 2,4-diaminobutyric acid (DABA)5, Gly6, Asn7, and Ser8
Table 1. Percent body weight change, serum chemistry and hematology following administra-tion of drug and excipient control
Figure 3. In vitro toxicity screen of occidiofungin. Cancer cell lines OVCAR8 (green line and triangles), SW1088 (blue line and circles), and Toledo2631 (orange lines and open squares) have an average TC50 value of 61 nM, 68 nM, and 70 nM, re-spectively

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