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Regions of very low H3K27me3 partition the Drosophila genome into topological domains

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Figure

Fig 1. Domains with very low H3K27me3. (A) ChIP enrichment profile of H3K27me3 in primary spermatocytes compared to Kc cell and 0–12 hrembryo H3K27me3 profiles and Kc cell Polycomb profile
Fig 2. Genomic features of D domains. (A) Profiles of selected histone modifications, chromatin components and housekeeping genes showingassociation with the D domain HMM state (green bars) based on the H3K27me3 profile in primary spermatocytes
Fig 3. D and E domains are strongly associated with TAD architecture. (A) Heatmap of 10 kb binned normalised Hi-C interactions across a 2 Mbcontrast to model 1 where TADs abut at simple interfaces, we suggest model 2 where prominent TADs (blue) are separat
Fig 5. D and E domains are topologically distinct. (A) Kc cell Hi-C interaction heatmaps at selected D and E domains with tracks “D” showing the Ddomains as green bars, “Hi-C” showing the Kc cell-derived TAD boundaries and “State” showing the 5-colour chro
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