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Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2- mediated signaling

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Academic year: 2020

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Figure

Figure 1: Suppression of DR5, but not DR4, expression increases cancer cell invasion. A–D.which DR5 was stably knocked down (A), knocked out (B), knocked down and then re-expressed (C) or knocked out and then re-expressed (D) as evaluated with Western blot
Figure 2: Knockdown of DR5 increases cancer cell metastasis in vivo. Both 801C-pLKO.1 and 801C-shDR5 cells were injected subcutaneously into nude mice
Figure 3: DR5 knockdown activates ERK and JNK/AP-1 signaling, increases TRAF2 levels and enhances MMP expression
Figure 4: ERK (A and C), JNK (B and D), c-Jun (E) and Fra-1 (F) mediate DR5 knockdown-induced cell invasion
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