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HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer

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Academic year: 2020

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Figure 1 hJC0152 inhibits the phosphorylation of sTaT3 in gC cells.BgC-823). Western blots showing the levels of p-sTaT3 and downstream targets in ags (1, 2, and 4 hours) or with different concentrations of hJC0152 (0, 5, 10, and 20 µM) for 4 hours
Figure 2 hJC0152 inhibits gC cell growth.Note: (A, B) Viability of ags and MKn45 cells treated with different concentrations of hJC0152 (0, 1, 5, 10, and 20 µM) for 0, 24, 48, and 72 hours was determined by CCK8 assay
Figure 3 hJC0152 inhibits the growth of MKn45 xenografts in vivo.positive rate of Ki-67 in different groups
Figure 4 hJC0152 induces apoptosis in gC cellsconcentrations of hJC0152 (0, 5, 10, and 20 µM) for 4 hours
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