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Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

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Academic year: 2020

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Figure 1 schematic illustration of gal(oct)-c-Mes assembled from coix seed oil (oil phase), coixan (passive targeting component), rh40 (surfactant), Peg400 (co-surfactant) and gal(oct) ester (active targeting ligand).Notes: Due to modification with medium carbon chain, the Gal segments were completely exposed outside the particles, thereby enhancing internalization by hepatoma carcinoma cells that was mediated by ligand-receptor recognition and ePr effect.Abbreviations: asgPr, asialoglycoprotein receptor; c-Mes, coix seed component-based microemulsions; ePr, enhanced permeability and retention; gal(oct)-c-Mes, octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components; PEG, polyethylene glycol.
Figure 2 Preparation and characterization of gal(oct).Notes: (A) synthetic pathway of gal(oct)
Figure 3 characterization of different microemulsions.Notes: (A) size and zeta potential of microemulsions under various ph environments
Figure 4 hepg2 cellular uptake studies.Notes: (A) Fluorescence images of hepg2 cells after incubation with various microemulsions at 37°c for 2 h
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