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A reversible block at the G1/S border during cell cycle progression of mouse embryos

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Academic year: 2020

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Fig. 1, Mouseembryostreatedwith150 ~IM mimosinefor (A) 4.5 hand(CI18.20h. At the end of the trearmenr period (4-5 hand18-20 h) none ofthese 4.cell stage embryosexhibited signs of degenerationor fragmentation.Blastocystformation after drug removal; 181embryos pretreated4-5 hand(D) embryospretreated18-20 h with 150 pM mlmosine(x200).
Fig. 2. Nuclei of 4-cell stagemouseembryoslabeledwith 3H-thymidinefor 60 min. Note in IAI an inrensive labeling in control embryos andlBI avery weak labeling in prerrE'ared embryoswith mln10sme15011Mfor 4 h (x2201.

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