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EGF and TGF alpha influence in vitro lung development by the induction of matrix degrading metalloproteinases

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Figure

Fig. 1. Organculturespictureof lung rudiments.Contro/lungexplants(CON)immediatelyafter dissectionand on days1-3 of cultureare showncom-pared to rhose treated with daily additionof 50ng/mlTGFa(TGFa).Eachrepresentsa differentlung and is representativeof 8-10
Fig. 3. Dose responseof EGF, TGFu, and mammalianpresencemorphometricanafysis2 pg/mlcollagenaseeffectsupon lung branching.Lung rudimentswere maintainedfor 3 daysIn theof the indicated concentrationsof EGF,TGFu,and mammaliancollagenase(CaL)

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