Yun-Zheng Le, Ph.D. Department of Medicine Section of Endocrinology & Diabetes University of Oklahoma Health Sciences Center
941, Stanton L. Young Blvd., BSEB 302G Oklahoma City, OK 73104, USA
Tel: (405) 271-1087; E-mail: [email protected] http://www.ouhsc.edu/Endocrinology/faculty/Le.asp EDUCATION
2004-2005: Faculty Leadership Program, the University of Oklahoma Health Sciences Center, USA. 1988-1994: Ph.D., Biology/Microbiology (with Dr. Leo Vining, FRSC), Dalhousie University, Canada. 1978-1982: B. Sc. Biochemistry, Fudan University, China.
PROFESSIONAL EXPERIENCE
2018-: Professor of Medicine (with tenure) and Adjunct Professor of Cell Biology and Ophthalmology, Colleges of Medicine and Graduate, the University of Oklahoma Health Sciences Center, USA.
2017-: Harold Hamm Chair in Diabetes Research, the University of Oklahoma Health Sciences Center, USA.
2013-: Mentoring Faculty, Oklahoma Center for Neuroscience, the University of Oklahoma Health Sciences Center, USA.
2007- Member, Harold Hamm Diabetes Center, the University of Oklahoma Health Sciences Center, USA.
2011- 2018: Associate Professor of Medicine (with tenure in 2013) and Adjunct Associate Professor of Cell Biology and Ophthalmology (2014), College of Medicine and Graduate, the University of Oklahoma Health Sciences Center, USA.
2012-2017: Inaugural Choctaw Nation Chair in Diabetes Research, the University of Oklahoma Health Sciences Center, USA.
2007-2011: Assistant Professor of Medicine (Tenure-track), College of Medicine, the University of Oklahoma Health Sciences Center, USA.
2007-2011: Adjunct Assistant Professor of Cell Biology, Colleges of Medicine and Graduate, the University of Oklahoma Health Sciences Center, USA.
2002-2006: Principal Investigator, Dean A. McGee Eye Institute, USA.
2000-2006: Assistant Professor of Research, Department of Cell Biology, the University of Oklahoma Health Sciences Center, USA.
1998- 2000: Senior Research Scientist with Dr. Brian Sauer, Developmental Biology Program, Oklahoma Medical Research Foundation, USA.
1996-1998: Visiting Fellow (Advisor: Dr. Brian Sauer), Laboratory of Biochemistry and Metabolisms, National Institute of Diabetes, Digestive and Kidney diseases//NIH, USA.
1994-1996: Postdoctoral Fellow (Advisor: Dr. Melanie J. Dobson), Biochemistry Department, Dalhousie University, Canada.
1988-1994: Graduate Research/Teaching Assistant and Ph.D. student (Advisor: Dr. Leo C. Vining, Royal Society Fellow of Canada), Biology Department, Dalhousie University, Canada. 1982- 1988: Engineer and Group Leader of Biochemical Reagents, Dong Feng Biochemical Reagent
Co., Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China. AWARDS, HONORS, SPECIAL RECOGNITION
2017-present: Harold Hamm Endowed Chair in Diabetes Research, Harold Hamm Diabetes Center, the University of Oklahoma Health Sciences Center, USA.
2020: Exceptional Reviewer, Investigative Ophthalmology & Visual Science (top Journal for
2019: Chair, Beyond Anti-VEGF Therapy—New Approaches in Diabetic Retinopathy Clinical Trials, Annual meeting of American Diabetes Association, San Francisco, California, USA. 2019: Nanqian (the best in Southern China) Lectureship (unsolicited), for work on blood-retina
barrier and neuroprotection in diabetic retinopathy (co-awardees: Drs. Steven J. Fliesler, Donald C. Hood, and Andrew J. Quantock), lecture(s) with highest academic honor at Xiamen University, Xiamen, China.
2016: Top 10 Diabetes Research Award (ranking: 7th, based on our work in Diabetes, 64:3554), Chinese Diabetes Society, China.
2014-2017: Visiting Professorship, Shanghai Jiaotong University School of Medicine, Shanghai, China.
2012-2017 Inaugural Choctaw Nation Endowed Chair in Diabetes Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
2012: Loris and David Rich Endowed Lectureship in Visual Sciences, Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama. USA. 2011: American Diabetes Association Magazine, Forefront, featured Investigator.
2010-2012: Visiting Professorship, School of Ophthalmology and Optometry, Wenzhou Medical College, China.
2009-2012: Task Group Member, Arnold and Mabel Beckman Initiative for Macular Research.
2008-2012: Visiting Professorship, Department of Ophthalmology, Xiangya Hospital of Central South University, China.
2007: Award for Outstanding Contribution to Vision Research (unsolicited), Hope for Vision of
Washington D.C.
2006: Young Investigator Travel Award, the XII International Symposium on Retinal Degeneration.
1998: NIH Fellows Award for Research Excellence (of 120 in over 3,000 NIH fellows), National Institutes of Health.
1996-1998: Visiting Fellowship, National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases.
1992: Patrick Letts Travel Award, Dalhousie University, Canada. PROFESSIONAL ACTIVITY
Professional Memberships
2006-present: American Diabetes Association.
2010-present: International Society for Eye Research.
2001-present: Association for Research in Vision and Ophthalmology. 2001-2015: American Association for the Advancement of Science. 2004-2006: American Society for Biochemistry and Molecular Biology. Service to Scientific Community
2007-present: Moderator, Sessions at Annual Meeting of the Association for Research in Vision and Ophthalmology.
2019: Chair, Beyond Anti-VEGF Therapy—New Approaches in Diabetic Retinopathy Clinical Trials, Annual Meeting of American Diabetes Association.
2019: Organizer, Special Interest Group: Müller glia in neuroprotection under diabetic and hypoxic conditions-Glia in blood-retina barrier disorders, Annual Meeting of the Association for Research in Vision and Ophthalmology.
2018-19: Moderator and Mentoring Faculty, Annual Chinese Congress of Research in Vision and Ophthalmology.
2016: Grant Reviewer Selection, Kentucky Science and Engineering Foundation.
2014: Organizer, Special Interest Group: RPE barrier does it matter? Annual Meeting of the Association for Research in Vision and Ophthalmology.
2009-2012: Member, Imaging, Stem Cell, and Cell Biology Task Groups, Arnold and Mabel Beckman Initiative for Macular Research (on atrophic age-related macular degeneration).
2004-present: Cre/lox plasmids distributor for NIH/NIDDK and Cre-driver mouse line distributor for vision
research community. Grant Review
2019-20: US National Science Foundation (NSF) Review Panelist (program not listed per NSF rule) 2017, 18, 19: Ad Hoc Grant Reviewer, NIH Disease & Pathology of Visual System Study Section 2013, 19, 20: Ad Hoc Grant Reviewer, Oak Ridge Associated Universities
2018-20: Ad Hoc Grant Reviewer, Florida Department of Health. 2019: Ad Hoc Grant Reviewer, Moorfields Eye Charity
2017: Ad Hoc Reviewer for Project Grants, Fight for Sight, United Kingdom.
2015-2017: Ad Hoc Reviewer, British MRC Neurosciences Research & Fellowship Grants 2014: Ad Hoc Grant Reviewer, NIH/NEI Special Emphasis Panel on Retinopathy 2013: Ad Hoc Grant Reviewer, NIH Biology of Visual System Study Section 2012-2013: Ad Hoc Grant Reviewer, Diabetes United Kingdom
2012: Ad Hoc Grant Reviewer, Foundation Fighting Blindness of Canada. 2009: Ad Hoc Grant Reviewer, NIH Cell Biology Integrated Review Group.
2015-present: Harold Hamm Diabetes Center Grant Review Committee, University of Oklahoma Health Sciences Center.
2006-present: Ad Hoc Grant Reviewer, Presbyterian Health Foundation.
2006-present: Ad Hoc Reviewer, Oklahoma University College of Medicine Alumni Association. Editorial Service
2020-present: Editorial board member, Journal of Modern Medicinal Chemistry
2018-present: Section Editor, Ophthalmology Forecast
2018-present: Editorial board member, E-Cronicon Ophthalmology
2018-present: Editorial board member, Ophthalmology Journal
2016-2017: Guest Editor, Special Issue on Diabetic Retinopathy, Vision Research
2017-2018: Editorial board member, World Journal of Translational Medicine
2012-2017: Editorial board member, Data Sets in Medicine (Ophthalmology)
2011-2018: Editorial board member, World Journal of Ophthalmology
Manuscript Review
2020-present: Journal of Diabetes Research
2020-present: Expert Opinion on Biological Therapy
2020-present: Journal of Modern Medicinal Chemistry
2020-present: Cell Cycle
2020-present: American Journal of Physiology - Endocrinology and Metabolism
2020-present: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
2019-present: Exploration of Medicine
2019-present: Frontiers in Immunology
2019-present: Current Molecular Medicine
2019-present: Current Pharmaceutical Design
2019-present: Drug Design, Development and Therapy
2018-present: Clinical Ophthalmology
2018-present: Current Medicinal Chemistry
2017-present: Clinical Obstetrics, Gynecology & Infertility
2017-present: Current Eye Research
2017-present: Diabetologia
2017-present: European Journal of Human Genetics
2017-present: Federation of American Societies for Experimental BiologyJournal
2017-present: International Ophthalmology
2017-present: Neural Regeneration Research
2017-present: Proceedings of the National Academy of Sciences (USA)
2017-present: Visual Neuroscience
2015-present: Scientific Report (Nature Group)
2015-present: Journal of Chemical Neuroanatomy
2015-present: Molecular and Cellular Endocrinology
2015-present: International J Ophthalmology and Eye Science
2015-present: International J diabetes
2014-present: Endocrine
2014-present: European J Pharmacology
2013-present: American Journal of Physiology- Heart and Circulatory Physiology
2013-present: Frontier in Physiology
2013-present: World Journal of Ophthalmology
2011-present: Journal of Inflammation Research
2011-present: Journal Neuroinflammation
2011-present: Experimental Diabetes Research
2010-present: Experimental Eye Research
2010-present: Investigative Ophthalmology & Visual Science
2010-present: Journal of Ophthalmology
2010-present: Journal of Visualized Experiments
2010-present: Laboratory Investigation (Nature Group)
2010-present: Letters in Drug Design & Discovery
2010-present: Molecular and Cellular Biochemistry
2010-present: Molecular Vision
2010-present: Ophthalmic Research
2010-present: PLoS One
2009-present: Journal of Cellular and Molecular Medicine
2008-present: Diabetes
2008-present: Vision Research
Consultantship
2017-2019: Cygen Biotech Limited, Shanghai, China. 2007-2012: Allergan Inc. Irvine, California. USA.
1998-2012: Animal facilities at Oklahoma Medical Research Foundation, OUHSC, and McGee Eye Institute, as a volunteer consultant.
PUBLICATIONS Journals
1. Zhang, S., Lyuboslavsky, P., Dixon, J.A., Chrenek, M.A., Sellers, J.T., Hamm, J.M., Ribelayga, C.P., Zhang, Z., Le, Y., Iuvone PM. (2020) Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG. Invest Ophthalmol Vis Sci. 61(6):24. doi:
10.1167/iovs.61.6.24.
2. Qiu, F., Zhu, M., Le, Y.*. (2019) Non-invasive diagnosis of regional alteration of retinal morphology and structure with optical coherence tomography in rodents, Adv. Exp Med Biol. 1185:151-155. doi:
10.1007/978-3-030-27378-1_25.
3. Ma H., Yang F., Butler M.R., Rapp J. Le Y.*., Ding X.Q. (2019) Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-gated Channel Deficiency. eNeuro 0119-19.2019
4. Xu, B., Zheng, H., Zhu, M., Le, Y.*. (2019) Critical role of trophic factors in protecting Müller glia: implication to neuroprotection in diabetic and in hypoxic retinal diseases, Adv. Exp Med Biol.
1185:469-473. doi: 10.1007/978-3-030-27378-1_77.
5. Yang, J., Chen, C., McLaughlin, T., Le, Y. Wang, J., Zhang, S.X. (2019) Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in diabetes. Diabetologia, doi:
10.1007/s00125-018-4776-y.
6. Royer, D.J., Elliott, M.E., Le, Y. Carr.D.JJ. (2018) Epithelial cells exhibit myeloid characteristics 1 and present antigen during HSV-1 keratitis. Invest Ophthalmol Vis Sci. 59:1512-1522. PMC5861930
7. Fu, S., Dong, S., Zhu, M. Le, Y.* (2018) VEGF as a trophic factor for Müller glia in hypoxic retinal diseases. Adv. Exp Med Biol. 1074:473-478. PMID: 29721978
8. Pyakurel, A., Balmer, D., Saba-El-Leil, M.K., Kizilyaprak, C., Daraspe, J., Humbel, B.M., Voisin, L., Le, Y., von Lintig, J., Meloche, S., Roduit, R. (2017) Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration. Mol Cell Biol. 37(24). pii: e00295-17.
PMC5705814.
9. Le, Y.* (2017) VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases. Vision Res
S0042-6989 (17) 30094-9. PMC5723217.
10. Butler, M.R., Ma, H., Yang, F., Belcher, J., Le, Y., Biel, M., Michalakis, S., Iuso, A., Krizaj, D., Ding, X.Q. (2017). Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J. Biol. Chem. 292:11189-11205. PMC5500788
11. Hu, J., Li, T., Du, X., Wu, Q.*, Le, Y.* (2017). G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. Vision Res. S0042-6989 (17) 30084-6. PMC5723215.
12. Zhang, Y., Cross, S. D., Lee, Y., Stanton, J. B., Marmorstein, A. D., Le, Y. Marmorstein, L. Y. (2017). RPE-specific deletion of murine Atg5 or Atg7 causes AMD-like features and retinal degeneration.
Mol. Vision, 23, 228-241. PMID: PMC5398883.
13. *Le Y, Zhu M, Anderson, RE (2016) Cre recombinase: you can’t live with it, and you can’t live without it. Adv Exp Med Biol. 854:725-30. PMID: 26427481.
14. Biswal M.R., Idelfonso C., Mao H., Seo S.J., Wang Z., Li H., Le Y, Lewin AS. (2016) Conditional Induction of Oxidative Stress in RPE: a Mouse Model of Progressive Retinal Degeneration. Adv Exp
Med Biol. 854:31-7. PMID: 26427390
15. Grabner C., Gandini M., Rehak R., Le Y., Zamponi GW., Schmitz, F. (2015) RIM1/2 Mediated Facilitation of Cav1.4 Channel Opening is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors. J. Neurosci. 23;35(38):13133-47. doi: 10.1523/JNEUROSCI.0658-15.2015.
16. Li L, Rao KN, Le Y, Hurd TW, Lillo C, Khanna H (2015) Loss of Retinitis Pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice. Cytoskeleton 72(9):447-54
PMC4715527
17. Fu S, Dong, S, Zhu M, Sherry DM, Wang Y, You Z, Haigh JJ, *Le Y (2015) Müller glia are a major cellular source of survival signals for retinal neurons in diabetes. Diabetes 64(10):3554-63.
PMC4587642. Receiving Top Ten Diabetes Research Award in China for 2015 (ranked 7th).
18. Sahu B, Sun W, Perusek L, Parmar V, Le Y, Griswold MD, Palczewski K, Maeda A (2015) Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J. Biol. Chem. 290(45):27239-47. doi: 10.1074/jbc.M115.682096. PMC4646373
19. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le Y, Subauste CS, Chen Y, Palczewski K, Maeda A (2015) Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J. Biol.
Chem. (290(48):29035-44. doi: 10.1074/jbc.M115.682310. PMC4661415
20. Wang J., Zhu M., *Le Y. (2015) Müller cell-derived VEGF in diabetic retinopathy. World J. Diabetes.
6 (5):726-33. doi: 10.4239/wjd.v6.i5.726. PMC4458501
21. Venkatesh A, Ma S, Le Y, Hall MN, Rüegg MA, Punzo C. (2015) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice., J Clin Invest. 125 (4):1446-58. PMC4396488
22. Ma S, Venkatesh A, Langellotto F, Le Y, Hall MN, Rüegg MA, Punzo C. (2015) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Exp Eye Res. 135:1-13. PMC4446177
23. Fu S., Zhu M., Wang Y. *Le Y. (2014) Efficient induction of productive Cre-mediated recombination in RPE. (Invited Research Article) Mol Vis 20:480-487. http://www.molvis.org/molvis/v20/480.
PMC3984040.
24. Dong S., Liu. Y.; Zhu, M., Xu, X., *Le, Y. (2014) Simplified system to investigate alteration of retinal neurons in diabetes. Adv Exp Med Biol. 801:139-43. (doi: 10.1007/978-1-4614-3209-8_18). PMID:
24664691.
25. Zhou K.K., Benyajati S., Le Y., Cheng R., Zhang W., Ma J.X. (2014). Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. 9(10):e108454. (doi: 10.1371/journal.pone.0108454), PMC4182699.
26. Ramamurthy V., Jolicoeur C., Koutroumbas D., Mühlhans J., Le Y., Hauswirth, W.W., Gießl A., Cayouette M. (2014) Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia, J. Neurosci. 34:13976 –13987.
27. Mao H., Seo S.J., Biswal M.R., Li H., Conners M., Nandyala A., Jones K., charffetter-Kochanek K., Le Y., Lewin A.S. (2014) Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest. Ophthalmol. Vis. Sci. 55:4613-27. (doi:
10.1167/iovs.14-14633). PMC4112607
28. Fu S., Zhu M., Ash J.D., Wang Y. *Le Y. (2014) Investigating the role of retinal Müller cells with approaches in genetics and cell biology., Adv Exp Med Biol. 801:401-5. (doi:
10.1007/978-1-4614-3209-8_51) PMID: 24664724.
29. Luo L., Uehara H., Olsen T., Das K.S., Zhang X., Simonis J.M, Jackman K., Archer B., Singh N., Miya T., Huang W., Ahmed F., Liu Y., Ambati J., Mamalis C., Chiodo V.A., Hauswirth W.W., Ferrara N., Baffi J., Gao G., Zygmunt K. Whitaker R., Lacal P.M., Orecchia A., Fu Y., Le Y., Jones A.D., Owen L., Holt D., Albuquerque R., Baehr W., Thomas K., Li D., Chalam K.C., Shibuya. M., Grisanti S., Wilson D.J., Ambati B.K. (2013). Photoreceptor Avascular Privilege is shielded by soluble VEGF receptor-1. eLife 2:e00324 (doi: 10.7554/eLife.00324). PMC3687373.
30. Nasonkin I.O., Merbs S.L., Lazo K., Oliver V.F., Brooks M., Patel K., Enke R.A., Nellissery J., Jamrich M., Le Y., Bharti K., Fariss R.N., Rachel R.A., Zack D.J., Rodriguez-Boulan E.J., Swaroop R. (2013) Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis, Development 140: 1330-41.
PMC3585665.
31. Chen Y., Sawada O., Kohno H., Le Y., Subauste C., Maeda T., Maeda A. (2013) Autophagy protects the retina from light-induced degeneration J. Biol. Chem. 288: 7506-18. PMC3597791
32. He C., Zhu H., Zhang W., Okon I., Wang Q. Li H., Le Y., Xie Z. (2013) 7-ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox4 and Atg4B. J. Am. Pathol. 183:626-37.
PMC3730774.
33. Siegert S., Cabuy E., Scherf B.G., Kohler H., Panda S., Le Y., Fehling H.J., Gaidatzis D., Stadler M.B., Roska B. (2012) Optional code and disease map for adult retinal cell types. Nat Neurosci.
15:487-95. (doi: 10.1038/nn.3032). PMID:22267162.
34. Lin M., Hu Y., Chen Y., Zhou K., Jin J., Zhu M., Le Y., Ge J., Ma J.X. (2012) Impacts of Hypoxia-inducible Factor-1 Knockout in the Retinal Pigment Epithelium (RPE) on Choroidal
Neovascularization. Invest. Ophthalmol. Vis. Sci. 53:6197–6206. PMC4113187.
35. Zhu, M., Bai, Y., Zheng, L. *Le, Y. (2012) Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development. Adv Exp Med Biol. 723:299-304. PMID:22183346
36. Zhong Y., Li J. Wang, J.J., Chen C., Tran JT, Saadi A, Yu Q, Le Y., Mandal N.A. Anderson R.E., Zhang S.X. (2012) X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium. PLoS One 7(6):e38616. PMC3371004.
37. Xu H., Liu J., Xiong S. Le Y., Xia X. (2012) Suppression of Retinal Neovascularization by Lentivirus- Mediated Netrin-1 Small Hairpin RNA. Ophthalmic Res 47:163-169 (DOI:10.1159/000331428).
PMC3251241.
38. Xu H., Song Z., Fu S., Zhu M., *Le Y. (2012) RPE barrier breakdown in diabetic retinopathy: seeing is believing. J. Ocular Biology, Diseases and Informatics 4:83–92. (DOI
10.1007/s12177-011-9068-4). PMC3342408.
39. Keady B., Le Y., Pazour G (2011) IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol. Biol. Cells 22: 921-30. PMC3069017.
40. *Le Y. (2011) Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations.
J. Ophthalmol. (doi:10.1155/2011/806783). PMC3021885.
41. Lin M., Chen Y., Jin J., Hu Y., Zhou K., Zhu M., Le Y., Ge J., Ma J.X. (2011) The role of retinal Müller cell-derived hypoxia-inducible factor-1 in retinal inflammation and neovascularization in diabetic retinopathy. Diabetologia 54:1554-66.
42. *Kusari J. (co-corresponding author), Padillo E.U., Zhou S., Ni M., Lalwani K., Bai Y. Wang J., Song,
Z. Zhu M. *Le Y. (co-corresponding author), Gil D.W. (2011) Effect of Brimonidine on Retinal and
Choroidal Neovascularization in Animal Models of Age-Related Macular Degeneration and Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 52:5424-31. PMC3176033
43. Xu H., *Le Y. Significance of outer blood-retina barrier breakdown in diabetes and ischemia (2011)
Invest. Ophthalmol. Vis. Sci. 52:2160-4. PMC3080181.
44. Ivanovic I., Anderson R.E., Le Y., Fliesler S., Sherry D., Rajala R. (2011) Deletion of the p85α Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration. Invest. Ophthalmol. Vis. Sci. 52:3775-83. PMC3109053.
45. Lange C., Heynen S., Tanimoto, N., Le Y., Meneau I., Seeliger M.W., Samardzija M., Grimm C. (2011) Normoxic activation of hypoxia inducible factors in photoreceptors provides transient protection against light induced retinal degeneration Invest. Ophthalmol. Vis. Sci. 52:5872-80.
46. Ivanovic I., Rajala A., Gupta V., Dighe R., Le Y., Anderson R.E., Rajala R. (2011) Phosphoinositide 3-Kinase Signaling in Retinal Rod Photoreceptors. Invest. Ophthalmol. Vis. Sci. 52:6355-62.
PMC3176013
47. Liu J., Xia X., Xiong S. Le Y., Xu H. (2011) Intravitreous high expression level of netrin-1 in patients with proliferative diabetic retinopathy. Eye Science (Yan Ke Xue Bao) 26 (2):35-42. PMC3445338.
48. *Le Y. (2010) Computer-assisted semi-quantitative analysis of choroidal density. Adv Exp Med Biol.
664:349-53. PMID: 20238035
49. Wang J., Xu X., Elliott M.H. *Le Y. (2010) Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes 59: 2297-2305. PMID: 20530741, PMC2927953.
50. *Le, Y. Bai, Y., Zhu, M., Zheng, L. (2010) Temporal requirement of RPE-derived VEGF in the formation of choroidal vasculature. J. Neurochem. 112: 1584–1592. PMID: 20067573; PMC2933813.
51. Zhu M., Zheng L., Ueki Y., Ash J.D., *Le Y. (2010) Unexpected transcriptional activity of the human
VMD2 promoter in retinal development. Adv Exp Med Biol. 664: 211-216. PMID: 20238019
52. Bai Y., Ma J., Guo J., Wang J., Zhu M., Chen Y., *Le Y. (2009) Müller cell-derived VEGF is a significant contributor to retinal neovascularization (cover article). J. Pathol. 219:446-454. PMID:
19768732
53. Ueki Y., Le Y., Chollangi S., Müller, W., Ash J.D., (2009) Preconditioning-induced protection of photoreceptors requires cell autonomous activation of the signal-transducing receptor gp130. Proc
54. Avasthi P., Watt C., Williams D., Le Y., Li S., Chen C., Frederick J., Baehr, W. (2009) Heterotrimeric Kinesin-II Mediates Trafficking of Membrane Proteins to Cone, but not Rod Outer Segments. J.
Neurosci 29:14287–14298. PMID: 19906976; PMC2788486.
55. Haruta M., Bush R.A., Kjellstrom, S., Le Y., Camasamudram V., Sieving P.A. (2009) Depleting Rac1 component of NADPH oxidase in mouse photoreceptors protects from photo-oxidative stress without affecting rod structure. Proc Natl. Acad. Sci. USA. 106:9397-9402. PMID: 19470639; PMC2685247.
56. Ueki Y., Ash J.D., Zhu M., Zheng, L., *Le Y. (2009) Expression of Cre recombinase in the retinal Müller cells (cover article). Vis. Res. 49: 615–621 (doi:10.1016/j.visres.2009.01.012). PMID:
19948109; PMC2787478.
57. Li F., Wicker L.D., Brush R.S., Elliott M.H., Le Y., Henry K.A., Anderson A.G., Zhao C., Sun X., Zhang. K., Anderson R.E. DHA does not protect ELOVL4 transgenic mice from retinal degeneration (2009)
Mol. Vis. 15:1185-1193 http://www.molvis.org/molvis/v15/a126. PMID: 19536303; PMC2697457.
58. Thiersch M., Lange C., Joly S., Heynen S., Le Y., Samardzija, M. Grimm C. (2009) Retinal neuroprotection by hypoxic preconditioning is independent of HIF-1 expression in photoreceptors.
European J. Neurosci 29: 2291–2302. PMID: 19508692
59. *Le Y., Zheng W., Rao P., Zheng L., Anderson R.E., Esumi N., Zack, J.D., Zhu M., (2008) Inducible expression of Cre recombinase in the RPE. Invest Ophthalmol Vis Sci. 49: 1248-1253. PMID:
18326755; PMC2711689.
60. Rajala A., Tanito M, Le Y., Kahn. R. C., Rajala, R.V. (2008) Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J. Biol Chem 283:19781-92. PMID:
18480052; PMC2443670.
61. Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., *Le Y. (2006) Loss of BCL-XL; increased rod photoreceptor susceptibility to bright light damage. Invest Ophthalmol Vis Sci. 47: 5583-5589. PMID:
17122152.
62. *Le Y., Zheng L., Zheng, W., Ash, J.D., and Anderson, R. E. (2006) Mouse opsin promoter controlled expression of Cre recombinase in transgenic mice, Mol Vis 12: 389-398. PMID: 16636658.
63. *Le Y., Ash, J.D., Al-Ubaidi, M.R., Chen, Y., Ma, J., and Anderson, R. E. (2004) Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice Mol Vis 10:1011-1018. PMID:
15635292.
64. Le Y., Gagneten, S., Larson, T., Santha, E., Dobi, A., Agoston, D. and Sauer B. (2003) Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy. J. Neurochem. 84: 689-697. PMID: 12562513
65. Le, Y., Miller, J. and Sauer, B. (1999). GFPcre Fusion Vectors with Enhanced Expression. Anal.
Biochem., 270:334-336. PMID: 10334853.
66. Le, Y., Gagneten, S., Tombaccini, D., Betheke, B. and Sauer, B. (1999). Nuclear targeting determinants in the Cre recombinase of phage P1. Nucleic Acids Res., 27:4703-4709. PMID:
10572169.
67. Chute, I., Le, Y., Ashley, T. and Dobson, M.J. (1997) The telomere-associated DNA from the short arm of human chromosome 20 contains a pseudotelomere structure and shares sequences with the subtelomeric regions of 4q and 18p. Genomics, 46, 51-60. PMID: 9403058
68. Gagneten, S., Le Y., Miller, J. and Sauer, B. (1997) Brief expression of a GFPcre fusion gene in
embryonic stem cells allows rapid retrieval of site-specific genomic deletions (cover-article). Nucleic
Acids Res., 25, 3326-3331. PMID: 9241248
69. Le, Y. and Dobson, M.J. (1997) Stabilization's of yeast artificial chromosome clones in a rad54
recombination-deficient host strain. Nucleic Acid Res. 25, 1248-1253. PMID: 9092636
70. Le, Y., Smith, K.C., Vining, L.C. and White, R.L. (1996) Mutants of Streptomyces akiyoshiensis
blocked in 5-hydroxy-4-oxonorvaline production. J. Antibiot., 49, 107-109. PMID: 8936306
71. Le, Y., He, J. and Vining, L.C. (1996) Streptomyces akiyoshiensis differs from other Gram-positive
bacteria in the organization of a core biosynthetic pathway gene for aspartate family amino acids.
Microbiol. 142, 791-798. PMID: 8609075.
from Streptomyces akiyoshiensis. J. Nat. Prod. 58, 1274-1277.
73. Le Y. (1994) Biosynthesis of 5-hydroxy-4-oxonorvaline. Ph.D. Thesis, Dalhousie University, Canada.
74. *Le, Y, Zhu. S. (1988) Purification of restriction endonuclease MspI. Huaxue Shiji 10, (1) 35-37.
*: Le Y as corresponding author. Methodology Review
1. Le, Y. and Sauer, B. (2001) Conditional gene knockout using Cre recombinase. In Mol Biotechnol.
Humana Press, Totowa, NJ. 17(3):269-75. PMID: 11434315. Books and Book Chapters
1. Hartnett, M.E. Baehr W., Le, Y. (2017) Diabetic retinopathy, an overview, Editorial for Vision Res
S0042-6989 (17) 30142-6. PMID: 28757399
2. Ueki Y., Chollangi S., Le Y., Ash J.D. (2010) gp130 Activation in Müller Cells is not Essential for Photoreceptor Protection from Light Damage. In Retinal Degenerations: Mechanisms and
Experimental Therapy. Anderson, R.E. et al. eds. Kluwer Academic/Plenum Publishers (New York):
pp 655-661. PMID: 20238070
3. *Le Y., Zheng L., Le, Y. Rucker III E.B., Anderson R.E. (2008) Role of BCL-XL in rod and cone photoreceptor survival. In Retinal Degenerations: Mechanisms and Experimental Therapy. LaVeil.
M.M. et al. eds. Kluwer Academic/Plenum Publishers (New York): pp 69-74. PMID: 18188930. 4. *Le Y., Ash, J.D., Al-Ubaidi, M.R., Chen, Y., Ma, J., and Anderson, R. E. (2006) Conditional knockout
system in photoreceptor cells. In Retinal Degenerations: Mechanisms and Experimental Therapy.
Hollyfield J. G. et al eds. Kluwer Academic/Plenum Publishers (New York): pp 173-178. PMID: 17249572.
5. Le Y. and Sauer, B. (2000) Conditional gene knockout using Cre recombinase. In Methods in
Molecular Biology: Protocol in Developmental Biology, Tuan R.S. and Lo C.W. eds. Humana Press,
Totowa, NJ. 136: II, 477-485. PMID: 10840735. *: Le Y. as corresponding author.
Non-authored publications
1. Magarvey N.A., Demain A.L. (2013) A tribute to Leo C Vining. J Antibiot (Tokyo) 66:359-360.
2. Clark N.A. (2011) Yun-Zheng Le, Ph.D.: Challenging the outcomes of diabetic retinopathy, Forefront, American Diabetes Association Magazine 8 (1):21-22.
3. Koury C.B. (2007) Genetic system offer option for studying the role of retinal Müller cells-Cover-story-editorial on Y. Le’s research program. Retina Today I (Sept/Oct):31.
National and International Meetings/Abstracts
1. Le Y. Severity of uveitis is regulated by RPE barrier function (Invited speaker and Faculty), XXIV Biennial Meeting of the International Society for Eye Research, October 25-29, 2020, Buenos Aires, Argentina (Abstract accepted, meeting cancelled due to COVID-19 pandemic).
2. Le Y., Zhu M. GDNF and BDNF are positive regulators for Müller cell viability through similar but divergent mechanisms, Annual Meeting of the Association for Research in Vision and Ophthalmology (Oral Presentation) May 2-7, 2020, Baltimore, Maryland, USA, (Abstract accepted, meeting cancelled due to COVID-19 pandemic).
3. Zhu M., Qiu F., Chucair-Elliott A., Fu S., Le Y. VEGF is a master regulator for neuronal integrity in diabetic retinopathy and hypoxic retinal diseases. European Ophthalmology Congress, (Invited Distinguished Speaker). April 6-7, 2020, Paris, France, (Abstract accepted, meeting cancelled postponed due to COVID-19 pandemic)
4. Le Y. VEGF is a master regulator for neuronal integrity in diabetic retinopathy and hypoxic retinal diseases. Eye-2019 (Plenary speaker). July 15-17, 2019 Fort Lauderdale, Florida, USA.
5. Le Y., Zhu M. VEGF is a master regulator of Müller glial health and integrity under diabetic or hypoxic stress, implication to neuroprotection during anti-VEGF therapies. June 12-15, 2019 NIH/NIGMS IDeA Central Region Conference, Oklahoma City, OK, USA.
6. Le Y., Qiu F. Zhu M. Mechanism of neurotrophin-mediated neuroprotection in diabetic and hypoxic conditions. 79 Scientific Sessions of America Diabetes Association, June 7-11, 2019, San Francisco, CA, USA.
7. Le Y. Müller glia in neuroprotection under diabetic and hypoxic conditions, Special Interest Group: Glia in blood-retina barrier disorders (Organizer, Moderator, and Speaker). Annual Meeting of the Association for Research in Vision and Ophthalmology, April 28-May 2, 2019, Vancouver, British Columbia, Canada.
8. Ma H., Yang F., Butler M.R., Rapp J. Le Y., Mikoshiba K., Biel M., Michalakis, S. Ding X.Q. The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency, Annual Meeting of the Association for Research in Vision and Ophthalmology, April 28-May 2, 2019, Vancouver, British Columbia, Canada.
9. Le Y., Qiu F. Zhu M. Mechanism of BDNF-mediated neuroprotection: critical role of Müller glia in diabetic retinopathy and age-related macular degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 28-May 2, 2019, Vancouver, British Columbia, Canada.
10. Butler M.R., Ma H., Yang F., Rapp J. Le Y., Mikoshiba K., Biel M., Michalakis, S. Ding X.Q. The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 28-May 2, 2019, Vancouver, British Columbia, Canada.
11. Le Y., Qiu F. Zhu M. VEGF regulates neuronal health in diabetic retinopathy and age-related macular degeneration through coordinated production and trophic effect of BDNF and GDNF (Invited talk). April 11-14, 2019, Outstanding Oversea Chinese Principal Investigator Forum, 11th Chinese Congress of Research in Vision and Ophthalmology, Xiamen, China.
12. Le Y. Fu, S. Zhu M. Potential role of VEGF signaling in Müller glia: implication to neuroprotection in long-term anti-VEGF therapies for diabetic retinopathy, age-related macular degeneration, and other hypoxic retinal vascular diseases (Invited Platform Presentation). XXIII Biennial Meeting of the International Society for Eye Research, September 9-13, 2018, Belfast, Northern Ireland, UK. 13. Zhu, M. Le Y. VEGF is a trophic factor for cone photoreceptor survival under hypoxia, an AMD-like
retinal environment. XVIIth International Symposium on Retinal degeneration, September 3-8, 2018, Killarney, Ireland.
14. Le Y. Zhu M. VEGF is a master regulator of Müller glial health and integrity under hypoxic stress, implication to neuroprotection in AMD and during anti-VEGF therapies. XVIIth International Symposium on Retinal degeneration, September 3-8, 2018, Killarney, Ireland.
15. Le Y. Zhu, M. Mechanisms of Müller glia-mediated neuroprotection in diabetic retinopathy and hypoxic retinal diseases, Annual Meeting of the Association for Research in Vision and Ophthalmology, April 29-May 4, 2018, Honolulu, Hawaii, USA.
16. Le, Y. Müller glia-mediated neuroprotection in diabetic retinopathy and hypoxic retinal diseases and its potential significance in anti-VEGF therapies, (Invited Platform Presentation) 10th Chinese Congress of Research in Vision and Ophthalmology, April 12-15, 2018, Changsha, China.
17. Le, Y. Synergistic effect among BDNF, GDNF, or VEGF on protecting Müller cells: implication in neuroprotection and anti-VEGF therapies, Federation of American Societies for Experimental Biology Meeting, June 25-30, 2017, Steamboat Springs, CO, USA.
18. Le, Y. Zhu, M. BDNF, GDNF, or VEGF in Müller cell viability: implication in neuroprotection in diabetic retinopathy and in anti-VEGF therapies, 77 Scientific Session of America Diabetes Association, June 8-12, 2017, San Diego, CA, USA.
19. Zhu, M. Le Y. Synergistic protection of Müller cell viability by BENF, GDNF, or VEGF in hypoxia: implication in neuroprotection in age-related macular degeneration and diabetic retinopathy and in anti-VEGF therapies. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 7-11, 2017, Baltimore, Maryland, USA.
20. Kapphahn R.J., Terluk M.R., Ebeling, M.C., Pierson M.J., Mar K., Gong H., Montezuma S., Le Y. Shirasaw T., Shimizu T. Ferrington, D.A. Elamipretide Protects RPE and Improves Mitochondrial Function in Models of AMD. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 7-11, 2017, Baltimore, Maryland, USA.
21. Zhu, M. Le Y. Neuroprotective role of GDNF and BDNF, XVIth International Symposium on Retinal degeneration, September 19-24, 2016, Kyoto, Japan.
22. Le Y. Role of Müller glia in AMD, XVIth International Symposium on Retinal degeneration, September 19-24, 2016, Kyoto, Japan.
23. Le Y. Zhu, M. Neuroprotective role of GDNF and BDNF in diabetic retinopathy, Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 5, 2016, Seattle, Washington, USA.
24. Pyakurel A., Balmer D., Zhu M., El Leil M. S., Daraspe J., Humbel B., Voisin L., Le Y., Von Lintig J., Meloche S., Roduit R. RPE cell specific loss of ERK1/2 leads to retinal degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 5, 2016, Seattle, Washington, USA.
25. Belcher J., Butler M.R., Ma H., Xu C., Biel M. Le Y., Michalakis, S., Luso A., Krizaj D., Ding X.Q. (2016) Inhibition of Endoplasmic Reticulum Calcium Channels Reduces Endoplasmic Reticulum Stress and Cone Death in CNG Channel-Deficient Mice, Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 5, 2016, Seattle, Washington, USA.
26. Le Y. Fu, S. Dong, S. Zhu, M. VEGF signaling in Müller glia, an essential neuro-protective mechanism in diabetes, Biology and Chemistry of Vision-FASEB meeting, June 14-19, 2015, Big Sky, Montana, USA.
27. Zhu, M., Shi K., Le Y. Mechanism of Cone Survival in Diabetic retinopathy, Biology and Chemistry of Vision-FASEB meeting, June 14-19, 2015, Big Sky, Montana, USA.
28. Le Y. Zhu, M. RPE Barrier Breakdown in Diabetes: Is It Real?-late breaking abstract, 75 Scientific Session of America Diabetes Association, June 5-9, 2015. Boston, Massachusetts, USA.
29. Zhang, Y., Cross, S. D., Lee, Y., Stanton, J. B., Le, Y., Marmorstein, A. D., and Marmorstein, L. Y. RPE-specific deletion of murine Atg5 or Atg7 causes AMD-like features and retinal degeneration. May 3-7, 2015, Denver, Colorado, USA.
30. Le Y. Zhu, M. Uniqueness and significance of RPE barrier breakdown in diabetic retinopathy, Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2015, Denver, Colorado, USA.
31. Le Y. Zhu, M. Fu, S. An essential role for Müller cells in neuro-protection in diabetic retinopathy (platform presentation), 17th Afro-Asia Congress of Ophthalmology, September 17-21, 2014, Xian, China.
32. Le Y., Zhu, M., Anderson R.E. Cre recombinase: you can’t live with it, and you can’t live without it. XVI International Symposium on Retinal Degeneration, July 13-18, 2014. Pacific Grove, California, USA.
33. Biswal M.R., Wang Z., Mao H., Li H., Le. Y., Lewin A. Reversal of oxidative stress in a mouse model of dry AMD. XXI Biennial Meeting of the International Society for Eye Research, July 20-24. 2014, San Francisco, California, USA.
34. Li L., Rao, K.N., Le Y., Hurd T.W., Delgado C.L., Khanna, H. Ablation of the Retinitis Pigmentosa 2 (Rp2) gene results in cone photoreceptor defect and aberrant microtubule dynamics. XXI Biennial
Meeting of the International Society for Eye Research, July 20-24. 2014, San Francisco, California, USA.
35. Le Y. Zhu, M. Mechanism of Cone Maintenance in Diabetic Retinopathy. 74 Scientific Session of America Diabetes Association, June 13-17, 2014. San Francisco, California, USA.
36. Le Y. RPE barrier, does it matter? Special Interest Group, (Organizer, Moderator, and Speaker) Annual Meeting of the Association for Research in Vision and Ophthalmology, May 4-9, 2014, Orlando, Florida, USA.
37. Le Y., Zhu, M. Efficient induction of productive Cre-mediated recombination in the retinal pigment epithelium (Platform presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 4-9, 2014, Orlando, Florida, USA.
38. Le Y., Cellular and molecular mechanisms in channeling signals for retinal neuron survival in diabetic retinopathy (platform presentation), 9th International Symposium of Ophthalmology, November 9-11, 2013, Guangzhou, China.
39. Le Y., Zhu M. Molecular and cellular interplay in channeling signals for retinal neuron survival in diabetes, 73 Scientific Session of America Diabetes Association, June 21-25, 2013. Chicago, Illinois, USA.
40. Zhu M., Le Y. Testing the effect of RPE barrier function regulators in vitro and in vivo. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 6-10, 2013, Seattle, Washington, USA.
41. Le Y. VEGF receptor-2 mediated neuro-protection is required for cone photoreceptor survival und hypoxic condition. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 6-10, 2013, Seattle, Washington, USA.
42. Le Y., Fu S. Xu H. Liu Y. Zhu M: Measurement of RPE barrier leakage de novo: usefulness in
investigating mechanism and therapeutics for diabetic retinopathy. XX Biennial Meeting of the International Society for Eye Research, July 21-25, 2012, Berlin, Germany.
43. Schultz R., Menning J., Ristow M. Le Y., Witte O.W., Schmeer C.: Frataxin overexpression in retinal Müller cells increases neuronal survival after acute retinal ischemia/reperfusion in vivo. XX Biennial Meeting of the International Society for Eye Research, July 21-25, 2012, Berlin, Germany.
44. Zhu M., Fu S., Dong S., Le. Y.: Müller cell integrity is essential to retinal neurons in diabetes. XVth International Symposium on Retinal Degeneration. July 16-21, 2012 Bad Gögging, Bavaria, Germany.
45. Le. Y. Fu S., Shi K., Dong S. Zhu M. Mechanism of Photoreceptor survival in diabetes. XVth International Symposium on Retinal Degeneration. July 16-21, 2012 Bad Gögging, Bavaria, Germany.
46. Le Y., Shi K. (2012) Rod degeneration accelerates cone photoreceptor death in diabetes, 72 Scientific Session of America Diabetes Association, June 8-12, 2012. Philadelphia, Pennsylvania, USA.
47. Luo L., Olsen T., Zhang X., Das S., Uehara H., Singh N., Miya T., Archer B., Le. Y., Ambati B.K.: Selective Cre/lox Flt-1 Ablation In RPE Induces CNV: A Novel Transgenic Murine CNV Model.
Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
48. Le Y. Song Z. Xu H., Carr D.J., Zhu M.: Modulating The Severity Of Uveitis By Altering RPE Barrier Function: Implication In Therapeutics. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
49. Ferreira P.A., Saha A., Haque E., Le Y., Webb M.: Conditional Knock-Out of Ran-binding protein 2 (RanBP2)/Nucleoporin 358 (NUP358) in the Retinal Pigment Epithelium Results in the Activation of Membrane to Nuclear Signaling Pathways and Hallmark Features of Age-Related Macular
Degeneration (AMD) (platform presentation). Annual Meeting of the Association for Research in
Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
50. Shi K., Le Y.: Cone Photoreceptors Are Vulnerable To Diabetes-induced Rod Photoreceptor Death. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
51. Hsu Y.C., Chuang J.Z. Chen J., Yan Y.T., Le Y. Sung C.H.: Regulates Opsin Trafficking And Outer Segment Morphogenesis. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
52. Fu S., Dong S. Le. Y. Müller Cell Is A Major Cellular Source Of Survival Signals For Photoreceptors In Diabetes. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
53. Lewin A.S., Krebs M.P. Gibson S., Jones K. Mao H., Le Y., Hauswirth W.: Image Registration Reveals Sites of Injury from Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2012, Ft. Lauderdale, Florida, USA.
54. Le Y., Fu S. Xu H.: Fluorescent Microscopic Imaging for RPE Barrier Leakage de novo: Simple
Technology Addresses Important Issue In Diabetic Retinopathy (platform presentation). ARVO/ISIE
Imaging Conference. May 4, 2012, Ft. Lauderdale, Florida, USA
55. Le Y., Fu S. Xu H. Zhu M.: Normal interaction between the RPE and choroidal vasculature is critical to retinal integrity. Annual Conference of Arnold and Mabel Beckman Initiative for Macular Research, January 25-29, 2012, Irving, California, USA.
56. Le Y., Fu S. Zhu M. Abnormal interaction between RPE and choriocapillaris causes age-dependent photoreceptor degeneration: implication in dry-AMD (Invited Platform Presentation) Annual Foundation Fighting Blindness Center Meeting, October, 14-15, 2011, Houston, Texas, USA. 57. Le Y., Liu Y.; Zhu M.; Hui X: Significance of Diabetes-induced Outer Blood-retina Breakdown and
its Relevance to Diabetic Macular Edema, 71st Scientific Session of America Diabetes Association, June 24-28, 2011. San Diego, California, USA.
58. Le Y., Liu Y., Zhu M., Hui X: Imaging Diabetes-induced Outer Blood-retina Breakdown: Implications in Diagnosis and Treatment of Diabetic Macular Edema. (Moderator) Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
59. Soojung S., Le Y., Conners M.S., Jones K.D., Hauswirth W., Lewin A., Generation of Early AMD Mouse Model by Induction of Oxidative Stress. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
60. Barabas P., Liu A., Xing W., Tong Z., Le Y., Anderson R.E., Zhang K., Bernstein P.S., Krizaj D.: Conditional Ablation of Retinal Elovl4 Reveals a Key Role in Synthesis of VLC-PUFAs and Photoreceptor Light Responses. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
61. Li, J., Zhong Y., Wang, J.J., Le Y. Mandal N.A. Zhang S.X.: Loss Of Xbp1 In The Aging RPE Reduces Autophagy And Exacerbates RPE Cell Death: A Novel Mechanism For Age-related Macular Degeneration (platform presentation). Annual Meeting of the Association for Research in
Vision and Ophthalmology, May 1-5, 2011, Ft. Lauderdale, Florida, USA.
62. Le Y., Liu Y.; Zhu M.; Hui X.: Visualizing and Quantifying Outer Blood-Retina Barrier Breakdown: Implications in Finding a Cure for Macular Edema. 10th Scientific Meeting of Association for Ocular Pharmacology and Therapeutics (platform presentation). February 17-20, 2011, Fort Worth, Texas,
USA.
63. Le Y., Zheng L., Bai Y., Zhu, M.: Mechanisms of atrophic AMD. 3rd Annual Conference of Arnold and Mabel Beckman Initiative for Macular Research, January 20-22, 2011, Irving, California, USA
64. Le Y., Hui X.: Visualizing Outer Blood-Retina Barrier Breakdown Under Pathological Conditions. XIX Biennial Meeting of the International Society for Eye Research (platform presentation), July
18-23, 2010. Montreal, QC, Canada.
65. Le Y., Hui X.: Pathophysiology Of Outer Blood-Retina Barrier Breakdown. XIX Biennial Meeting of the International Society for Eye Research, July 18-23. 2010, Montreal, QC, Canada.
66. Zhang S.X., Zhong Y., Li, J., Le Y. Wang, J.J.: Transcriptional Regulation of Anti-Oxidant Genes in the RPE. XIV International Symposium on Retinal Degeneration (platform presentation) July 13-17,
2010 Mont Tremblant, QC, Canada.
67. Le Y., Zheng L. Bai Y., Zhu M.: Choroidal circulation and geographic atrophy. XIV International Symposium on Retinal Degeneration. July 13-17, 2010, Mont Tremblant, QC, Canada.
68. Gibson S., Lewin A., Liu, J, Le Y., Hauswirth W.: Generation of mouse model of atrophic retinal degeneration by induction of oxidative stress. XIV International Symposium on Retinal Degeneration (platform presentation). July 13-17, 2010, Mont Tremblant, QC, Canada.
69. Le Y., Wang, J., Xu H.: Pathophysiology Of Outer Blood-Retina Barrier Breakdown (Session Moderator). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
70. Zhong Y., Li J., Wang J. Le Y., Zhang S.: X-Box Binding Protein 1 is a Novel Regulator of Anti-Oxidant Genes in the RPE. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
71. Barabas P., Huang W., Xing W., Rao A., Le Y., ChenC.-K.J., Krizaj D.: Store-Operated Calcium Entry Sustains Increased Calcium Level in Photoreceptor Cells and Affects Vision in the Mouse. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
72. Lin M., Chen Y., Jin J., Hu Y., Zhou K., Zhu M., Le Y., Ma J.-X.: The Role of Müller Cell-Derived Hypoxia-Inducible Factor (HIF)-1 on Retinal Neovascularization. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
73. Xu H. Le Y.: Cellular Mechanism and Treatment of Outer Blood-Retina Barrier Breakdown in Uveitis (Platform Presentation). Annual Meeting of the Association for Research in Vision and Ophthalmology, May 2-6, 2010, Ft. Lauderdale, Florida, USA.
74. Lewin A., Gibson S., Liu, J., Hauswirth W., Le Y.: Generation of a Mouse Model of Early AMD by Induction of Oxidative Stress. May 2-6, 2010, Ft. Lauderdale, Florida, USA.
75. Baehr W., Watt C.B., Williams D.S., Le Y., Li S., Chen C-K., Frederick J.M., Avasthi P.: Heterotrimeric Kinesin-2 is Required for Trafficking of Membrane Proteins to Cone, but Not Rod, Outer Segments. FASEB summer research meeting, June 14-19, 2009. Snowmass, Colorado, USA.
76. Ueki Y., Le Y., Wang, J., Chucair-Elliott, A., Ash, J.D.: Photoreceptor-specific knockouts of either gp130 or STAT3 accelerate inherited retinal degeneration: implication for chronic stress-induced neuroprotection. FASEB summer research meeting, June 14-19, 2009. Snowmass, Colorado, USA.
77. Guo J., Le Y.: Role of BCL-XL in Photoreceptor Survival Under Diabetes and Hypoxic Stress. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
78. Thiersch M., Lange C., Joly S., Le Y., Heynen S., Samardzija M., Grimm, C.: Hypoxia-Inducible-Factor 1 Ablation in a Model of Retinal Neuroprotection by Hypoxic Preconditioning. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
79. Ueki Y., Le Y., Ash, J.D.: Activation of the Signal-Transducing Receptor gp130 in Photoreceptors Is Essential for Endogenous Protection from Retinal Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
80. Seo S., Le Y. Hauswirth W., Lewin A.: Early AMD Mouse Model by Reduction of MnSOD2 Using the Cre-LoxP Recombination System. Annual Meeting of the Association for Research in Vision
and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
81. Baehr W., Watt C.B., Williams D.S., Le Y., Li S., Chen C-K., Frederick J.M., Avasthi P.: Heterotrimeric Kinesin-2 is Required for Trafficking of Membrane Proteins to Cone, but Not Rod, Outer Segments. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
82. Wang, J., Le Y.: The Role of the Müller Cell-Produced VEGF in Inflammatory Response During the Pathogenesis of Diabetic Retinopathy. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
83. Rajala R.V., Tanito M., Le Y., Allen D.T., Kahn R.C., Neel B.G., Rajala A.: Insulin Receptor Survival Signaling in Rod Photoreceptors Is Regulated Through Rhodopsin-Controlled Protein Tyrosine Phosphatase 1B Activity. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
84. Ivanovic I., Le Y. Anderson, R.E., Rajala R.V.: Deletion of the p85 Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
85. Bai Y., Ma J.-X., Le Y.: The Role of Retinal Müller Cell-Produced VEGF in Ischemia Induced Vascular Leakage. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
86. Le Y., Guo J., Zhu M.: Genetic Disruption of Müller Cell-Produced VEGF Does Not Affect Retinal Development and Integrity: Implication in Anti-VEGF Therapeutics. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 3-7, 2009, Ft. Lauderdale, Florida, USA.
87. Le Y., Guo J., Wang J., Zhu, M.: Dissecting The Role Of Müller Cell-Produced VEGF In Diabetic Retinopathy. 69th Scientific Session of America Diabetes Association, June 5-9, 2009. New Orleans, Louisiana, USA.
88. Zhu M., Zheng L., Ueki Y., Ash J.D., Le Y.: Expression of Cre recombinase in the retinal Muller cells. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
89. Ash J.D., Chollangi S. Le Y., Ueki Y., Wang J.: The AKT Pathway is Required for Neuroprotection in the Retina from Acute Injury While the gp130/STAT3 Pathway is Required for Protection from Chronic Stress. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
90. Baehr W., Le Y., Williams D., Frederick J., Avasthi P.: Kinesin-II Regulates Intraflagellar Transport of Membrane-associated Proteins to the Cone Photoreceptor Outer Segments. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
91. Ueki Y., Chollangi S. Wang J. Le Y., Ash J.D.: Signal-transducing Receptor gp130 is Essential for Endogenous Protection of Photoreceptors from Light Damage. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
92. Le Y., Zheng L., Bai Y., Zhu, M.: Age-dependent photoreceptor degeneration caused by the loss of the RPE-produced VEGF. XIII International Symposium on Retinal Degeneration, September 18-23, 2008, Ermeishan, China.
93. Le Y., Zhu M, Bai Y.: Retinal Pigment Epithelium in Diabetic retinopathy. 68th Scientific Session of America Diabetes Association, June 6-10, 2008. San Francisco, California, USA.
94. Ash J.D., Ueki Y., Le Y., Chollangi S.: Evidence That Leukemia Inhibitory Factor (LIF) Protects Photoreceptors From Light Damage Independent Of Müller Cell Activation By LIF. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
95. Le Y., Bai Y., Zhu M.: Relationship Between the RPE-Produced VEGF and the Outer Blood-Retina Barrier Function. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
96. Avasthi P., Le Y., Williams D., Frederick J., Baehr W.: Kinesin-II Regulates Transport of Membrane-Associated Proteins to the Cone Photoreceptor Outer Segments. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA. 97. Bai Y., Zhu M., Le Y.: Temporal Requirement of the RPE-Produced VEGF in Choroidal
Development. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
98. Rajala R., Rajala A., Le Y., Neel B. G. Tanito M: Enhanced Insulin Receptor Activated Neuroprotective Survival Signal in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene in Rod Photoreceptor Cells. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 26-May 1, 2008, Ft. Lauderdale, Florida, USA.
99. Le Y.: Function of the retinal Müller cell-produced VEGF in diabetic retinopathy. ARVO 2007 Summer Eye Research Conference, July 15-18, 2007, Warwick, Rhode Island, USA.
100. Le Y., Ma J., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., and Zhu, M.: Role of the retinal Müller cells in retinal neovascularization. 67th Scientific Session of America Diabetes Association, June 22-26, 2007. Chicago, Illinois, USA.
101. Le Y.: Contribution of the RPE to the bright light induced photoreceptor damages. FASEB summer research meeting, June 16-21, 2007. Snowmass, Colorado, USA.
102. Le Y., Ma J., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., and Zhu, M: Role of the retinal Müller cells in retinal neovascularization (platform presentation). Annual Meeting of the Association for
Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
103. Rajala R., Le Y., Lee Y., Rajala A., Kahn R., and Tanito M: Photoreceptor Specific Deletion of Insulin Receptor Results in Light-Induced Retinal Degeneration. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
104. Le Y.: Temporal and spatial gene activation and inactivation in the retina using Cre/lox strategies.
Cre-driver Lines for Use in the Tissue-Specific Deletion of Genes in Multiple Ocular Tissues (invited as a platform presenter and moderator) - Special Interest Group. Annual Meeting of the Association
for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
105. Le Y., Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., Le, Y., Zhu, M.: Role of anti-apoptotic protein BCL-XL in photoreceptor survival (invited as platform presentation), 2nd Shanghai
International Conference on Physiological Biophysics-Audition & Vision, November 3-7, 2006, Shanghai, China.
106. Le Y., Ma J., Zheng L., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., Zhu, M.: Role of the RPE-produced VEGF In choriocapillaris integrity. XII International Symposium on Retinal Degeneration (platform presentation), October 23-28, 2006, San Carlos de Bariloche, Argentina.
107. Le Y., Zheng L., Agbaga M., Rucker III E.B., Anderson R.E.: Loss of BCL-XL causes increased rod photoreceptor susceptibility to bright light damage. XII International Symposium on Retinal Degeneration, October 23-28, 2006, San Carlos de Bariloche, Argentina.
108. Zheng L., Anderson R.E., Agbaga M., Rucker III E.B., Le Y.: Loss of BCL-XL causes increased rod photoreceptor susceptibility to bright light damage. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 4, 2006, Ft. Lauderdale, Florida, USA.
109. Le Y., Zheng L., Zheng, W. Chen Y., Gerber. H.P., Ferrara N., Ma J.: Function of the RPE-produced VEGF in the outer blood retina barrier. Annual Meeting of the Association for Research in Vision and Ophthalmology, April 30-May 4, 2006, Ft. Lauderdale, Florida, USA.
110. Le Y., Rao P., Zheng L., Chen Y., Zheng L., Gerber. H.P., Ferrara N., Anderson R.E., Esumi N., Zack D.J., Ma J.: Inducible RPE-specific gene knockout and its application in gene function analysis. FASEB summer research meeting. June 18-23, 2005. Tucson, Arizona, USA.
111. Zheng L., Rao P., Zheng W., Le Y.: Glucose transport in the retina. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2005, Ft. Lauderdale, Florida, USA.
112. Le Y., Rao P., Zheng L., Zheng W. Ash J.D., Esumi N., Zack J.D., Anderson R. E.: Inducible gene knockout system in the retinal pigmented epithelium. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 1-5, 2005, Ft. Lauderdale, Florida, USA.
113. Zheng L., Rao P., Zheng W., Anderson R. E., Le Y.: Bcl-xl is involved in neuro-protection in the retina. April 1-2, 2005. Foundation Fight for Blindness, Southwest Regional Meeting, Dallas, Texas, USA.
114. Le Y., Ash J.D., Al-Ubaidi M.R., Chen Y., Ma J., Anderson R. E.: Conditional knockout system cone photoreceptor cells. XIth International Symposium on Retinal Degeneration, August 23 - 28, 2004, Perth, Western Australia.
115. Le Y., Ash J.D., Al-Ubaidi M., Anderson, R.E.: Conditional knockout system in cone photoreceptor cells. Annual Meeting of the Association for Research in Vision and Ophthalmology. April 25-29, 2004, Ft. Lauderdale, Florida, USA.
116. Le Y., Kontas C., Agbaga M. Ash J.D., LaVail M.M., Anderson R.E.: Conditional Knockout Systems in Retinal Cells. FASEB summer research meeting. June 21-26, 2003. Tucson, Arizona, USA. 117. Le Y., Kontas C., Agbaga M. Ash J.D., Anderson R.E.: Generation and characterization of
photoreceptor-specific Cre transgenic mice. Annual Meeting of the Association for Research in Vision and Ophthalmology. May 4-9, 2003, Ft. Lauderdale, Florida, USA.
118. Le Y. Conditional gene expression in the retina. March 28-29, 2003, Foundation Fight for Blindness Southwest Regional Meeting, Houston, Texas, USA.
119. Le Y., Agbaga M, Anderson, RE. Molecular cloning and expression of a phosphatidylinositol phosphate kinase from rat retina. Annual Meeting of Association for Research in Vision and Ophthalmology. May 2002, Fort Lauderdale, Florida, USA.
120. Le Y. Cell-type specific knockout system in retina. April, 2002, Foundation Fight for Blindness Southwest Regional Meeting, Oklahoma City, Oklahoma, USA.
121. Le Y., Gagneten S., D. Agoston D., Larson T., Sauer B: Expression of proenkephalin-lacZ fusion
gene in transgenic mice generated with a Cre-mediated knock-in strategy. IX International Symposium on Retinal Degeneration, October, 2000, Durango, Colorado, USA.
122. Le Y., Gagneten S., Larson T., Sauer B. (invited): Nuclear target determinants of Cre recombinase and the use of Cre-loxP system in manipulating mouse genome. The Second International Cao
Tian-Qin Memorial Symposium on Protein Research, June, 2000, Shanghai, China.
123. Soukharev S. Le Y., Sauer B: High frequency genomic targeting in ES cells by Cre recombinase. Conditional Genetic Technologies in the Mouse, First Cold Spring Harbor Workshop on Emerging Technologies for Cancer Research. September, 1998, Cold Spring Habor, New York, USA.
124. Le Y., Agoston D., Gagneten S., Larson T. Sauer B.: Functional dissection of the proenkephalin promoter in the mouse using Cre-mediated targeting. Mouse Molecular Genetics Meeting, September 1998, Cold Spring Habor, New York, USA.
125. Le Y., Gagneten S. Larson T., Miller J, Sauer B.: Use of GFPcre fusion gene for FACS sorting of
DNA "pop-outs" in ES cells and for tracing Cre expression in transgenic mice. NIH Research Festival, October, 1997, Bethesda, Maryland, USA.
126. Le Y., Gagneten S. Larson T., Miller J, Sauer B.: Brief Expression of a GFPcre fusion gene in embryonic stem cells allows rapid retrieval of site-specific deletions. 17th International Congress of Biochemistry and Molecular Biology, August, 1997, San Francisco, California, USA.
127. Dobson M.J., Le Y., Chute I., Ashley T.: The telomere-associated DNA from the short arm of human chromosome 20 contains an interstitial tract of telomeric repeats. The First Canadian Telomere Workshop, May, 1997. Toronto, Ontario, Canada.
128. Le Y., Dobson M. J.: Development and use of improved yeast artificial chromosome vectors and host strains: stabilization of yeast artificial chromosome clones in a rad54 recombination-deficient
129. Dobson, M. J., Le Y.: Development and use of improved yeast artificial chromosome vectors and host strains. Genome Canada 95. April, 1995. Toronto, Ontario, Canada.
130. Le Y., He J., Vining, L.C.: Cloning and sequence of the aspartate semialdehyde dehydrogenase gene from the 5-hydroxy-4-oxonorvaline producer, Streptomyces akiyoshiensis. 7th International
Symposium on Genetics of Industrial Microorganisms. June 1994. Montreal, Quebec, Canada. 131. Le Y. and Vining L.C. (invited): Biosynthesis of 5-hydroxy-4-oxonorvaline and asparatate family
amino acids in Streptomyces akiyoshiensis. First International Workshop on Antibiotics "Antibiotics,
93". November, 1993, Havana, Cuba.
132. Le Y., Wright J., Vining L.C., Smith K.C., White R.L.: Biosynthesis of 5-hydroxy-4-oxonorvaline: location of the branch point in the aspartate family pathway. 42 Annual Canadian Society of Microbiologist meeting. June, 1992, St. John's, New Foundland, Canada.
133. Le Y., Smith K.C., Vining, L.C, White, R.L.: Isolation and Characterization of mutants blocked in the aspartate pathway and in the biosynthesis of 5-hydroxy-4-oxonorvaline. 8th International Symposium on Actinomycete Biology. August, 1991, Madison, Wisconsin, USA.
Invited talks
1. Physiological and pathological function of VEGF: lesson learned in exploring treatment for diabetic retinopathy and age-related macular degeneration, November 20, 2019, Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
2. VEGF is a master regulator for neuronal integrity in diabetic retinopathy and hypoxic retinal diseases. Eye-2019. July 15-17, 2019 Fort Lauderdale, Florida, USA.
3. Genetic analysis of retinal degeneration, April 17, 2019. Department of Ophthalmology, Shanghai No. 6 people’s Hospital, Jiaotong University School of Medicine, Shanghai, China.
4. VEGF regulates neuronal health in diabetic retinopathy and age-related macular degeneration through coordinated production and trophic effect of BDNF and GDNF April 11-14, 2019, 11th Chinese Congress of Research in Vision and Ophthalmology, Xiamen, China.
5. VEGF is a master regulator for neuronal integrity in diabetic retinopathy and hypoxic retinal diseases, Nanqian Lecture, April 10, 2019, Xiamen University School of Medicine, Xiamen, China.
6. Physiological function of VEGF: relevance to anti-VEGF therapies for diabetic retinopathy and wet age-related macular degeneration. April 9, 2019. Department of Ophthalmology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
7. Potential role of VEGF signaling in Müller glia: implication to neuroprotection in long-term anti-VEGF therapies for diabetic retinopathy, age-related macular degeneration, and other hypoxic retinal vascular diseases. September 9-13, 2018. XXIII Biennial Meeting of the International Society for Eye Research, Belfast, Northern Ireland.
8. Müller glia-mediated neuroprotection in diabetic retinopathy and hypoxic retinal diseases and its potential significance in anti-VEGF therapies, April 12-15, 2018, Outstanding Oversea Chinese Principal Investigator Forum, 10th Chinese Congress of Research in Vision and Ophthalmology, Changsha, China.
9. VEGF as a functional regulator of retinal neurons. October 14, 2017, Shanghai Jiaotong University School of Medicine, Shanghai, China.
10. "Müller glia is a major modulator for vascular function and neuronal integrity in hypoxic retinal diseases", March 7, 2017. Department of Cellular & Molecular Physiology, Pennsylvania State University, Hershey, Pennsylvania, USA.
11. Anti-VEGF therapy, is it safe? August 23, 2016, Department of Ophthalmology, Shanghai No. 6 people’s Hospital, Jiaotong University School of Medicine, Shanghai, China.
12. Retinal pathobiology (acceptance lecture for a visiting professorship), September 3, 2014, Shanghai Jiaotong University School of Medicine, Shanghai, China.
13. Diabetic retinopathy, it is not just endothelial barrier breakdown, August 28, 2014, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
14. Pathogenic mechanisms of diabetic retinopathy, perspectives from a cell biologist, November 13, 2013, Vascular Biology Center, Georgia Regents University, Augusta, Georgia, USA.
15. Cellular mechanisms of diabetic retinopathy, November 6, 2013, Jiao-tong University affiliated Shanghai No. 6 Peoples’ Hospital, Shanghai, China.
16. Dissecting the functions of VEGF: each protein has its Yin and Yang, March 14, 2013 Department of Ophthalmology, University of Oklahoma Health Sciences Center and Dean A. McGee Eye Institute, Oklahoma City, OK, USA.
17. Diabetic retinopathy: it is not just endothelial barrier dysfunction, March 14, 2013 Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
18. Dissecting the mechanisms of diabetic complication in the retina, December 5, 2012, Loris and David Rich Endowed Lecture in Visual Science, the University of Alabama at Birmingham, Birmingham, Alabama, USA.
19. Diabetic retinopathy: it is not just retinal vascular dysfunction, December 5, 2012, Department of Ophthalmology, the University of Alabama at Birmingham, Birmingham, Alabama, USA.
20. What's new about the cellular mechanism of diabetes-induced blood-retina barrier breakdown? June 7, 2012, Wilmer Ophthalmological Institute, John Hopkins University School of Medicine, Baltimore, Maryland, USA.
21. RPE Barrier Breakdown in Diabetes, seeing is believing, May 29, 2012, Annual Meeting of Shichuan Academy of Medical Sciences and Society of Ophthalmology, Chengdu, China.
22. New Development in retinal biology research, May 28, 2012, Shichuan Provincial People’s Hospital, Chengdu, China.
23. RPE Barrier Dysfunction in Diabetes, May 25, 2012, Tong-ji University School of Medicine, Shanghai, China.
24. New trends in research for diabetic retinopathy, May 24, 2012, Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, China.
25. Pathological and beneficial roles of retinal Müller cells in diabetic retinopathy, May 21, 2012, Department of Ophthalmology, Jiao-tong University affiliated Shanghai No. 6 Peoples’ Hospital, Shanghai, China.
26. Diabetes-induced RPE barrier breakdown: seeing is believing. September 29, 2011, Symposium of Dean A. McGee Eye Institute New Research Building Dedication. Oklahoma City, OK, USA.
27. Physiological and pathological functions of VEGF in the eye. May 26, 2011, Department of Ophthalmology, Medical School of University of Texas at Galveston, TX, USA.
28. Dissecting the cellular mechanisms of diabetic retinopathy. December 2, 2010, Department of Cell Biology and Human Anatomy, University of California, Davis, California, USA.
29. Lessons learned from mice about retinal biology and diseases. November 15, 2010, Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.
30. The “good” and the “bad” side of VEGF. October 21, 2010. Department of Neural & Behavioral Sciences, Pennsylvania State University, Hershey, Pennsylvania, USA.
31. Diabetic retinopathy: Müller cells matter: a 3-cover-story tale. August 10, 2010. Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, China.
32. Essential role of Müller cells in retinal inflammation and vascular lesion: cellular mechanisms of diabetic retinopathy. July 31, 2010. Second Conference on the New Development in Ophthalmology. Department of Ophthalmology, Xiang-Ya Hospital of Central South University, Changsha, China. 33. Cellular mechanism of VEGF action in the eye. June 7, 2010. Department of Pharmacology and
Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
34. Mechanisms of retinal degeneration and diseases. September 24, 2008. Department of Ophthalmology, Xiang-Ya Hospital of Central South University, Changsha, China.
35. Cellular Mechanisms of diabetic retinopathy. November 29, 2007. Allergan Inc. Irvine, California. 36. Temporal and spatial gene activation and inactivation in the retina using Cre/lox strategies. Cre-driver
Group. Annual Meeting of the Association for Research in Vision and Ophthalmology, May 5-10, 2007, Ft. Lauderdale, Florida, USA.
37. Mechanisms of retinal degeneration and diseases. November 17, 2006. Institute of Neurobiology, Fudan University, Shanghai, China