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2014 CPT Code Updates
This publication is a summary of The American Medical Association Current Procedural
Terminology (CPT) codes published in ARUP's Laboratory Test Directory effective January 1, 201
4
.
Tests not listed in this summary do not have CPT code changes at this time.
The American Medical Association Current Procedural Terminology (CPT) codes published in
ARUP’s Laboratory Test Directory are provided for informational purposes only. The codes reflect
our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT
codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that
clients confirm CPT codes with their Medicare Administrative Contractor (MAC), as requirements
may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no
responsibility for billing errors due to reliance on the CPT codes published.
Please direct any questions regarding CPT coding to the payer being billed.
Test Number
Test Name
2014 CPT Code(s)
0040113 PAX-FKHR Translocation by RT-PCR 81401 x2
0040114 SYT-SSX, t(X;18) Transloc by RT-PCR 81401 x2
0040137 KIT (D816V) Mutation by PCR 81402
0040168 JAK2 Gene, V617F Mutation, Quantitative 81270
0040174 NPM1 Mutation, PCR-Fragment Analysis 81310
0040203 Chorionic Villus, FISH 88271 x5; 88275 x5; 88291
0040227 IGHV Mutation Analysis by Sequencing 81263
0040248 KRAS Mutation Detection 88381; 81275; 81403
0049390 ERBB2 (HER2/neu) Amplification by PCR 88381; 81479
0050157 Hypersensitivity Pneumo Extended Panel 86003 x3; 86005; 86331 x7; 86606 x5 0050444 RUNX1-RUNX1T1 (AML1-ETO) t(8;21) RT-PCR 81401
0050446 MLL-AFF1 (MLL-AF4) t(4;11) RT-PCR 81401
0050543 Fragile X (FMR1) Diagnostic, Fetal 81243;81244; 81265
0051067 HLA DRB3, 4, 5 81382
0051220 EWS-FLI1 Translocations by RT-PCR 81401
0051245 JAK2 Gene, V617F Mutation, Qualitative 81270
0051262 Ewing's Sarcoma ERG Transloc by RT-PCR 81401
0051348 HHT, Deletion and Duplication 81405 (ENG)
81479
0051381 HHT, Sequencing 81406 (ENG)
81479 0051382 HHT, Sequencing and Deletion/Duplication 81406 (ENG)
81405 (ENG)
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0051510 Juvenile Polyposis (SMAD4) Sequencing 81406
0051682 PCD (SLC22A5) Sequencing 81405
0051740 Microsatellite Instability by PCR 88381; 81301
0051750 BRAF with Reflex to MLH1 Methylation 88381; 81210; If reflexed, add 81479
0051755 Molar Pregnancy, 16 DNA Markers 81265; 88381
0051786 Alport Syndrome (COL4A5) Sequencing 81408
0051830 Allergen, Indoor 86003 x6; 86005
0055037 Allergen, Animal, Feather Mix 86005
0055114 Allergen, Inhalant/Food, Pro 1 86003 x28; 86005
0055120 Allergen, Animal, Dander, Feather 86003 x4; 86005
0055129 Allergen, Inhalant/Food, Western 86003 x23; 86005
0055305 Allergen, Inhalant, Environment Pro 10 86003 x9; 86005
0055307 Allergen, Inhalant/Food, Environment Pro 86003 x16; 86005
0055346 TCF3-PBX1 (E2A-PBX1) t(1;19) RT-PCR 81401
0055368 Allergen, Inhalant, Multiallergen Qual 86005
0055553 BCR-ABL1, t(9;22) Qual by RT-PCR 81206; 81207
0055557 IGH-CCND1 (BCL-1/JH) t(11;14) PCR 81401
0055567 T-Cell Clonality Screening by PCR 81342
0055616 IGH-BCL2 (BCL-2/JH) t(14;18) PCR 81402
0055691 BIRC2-MALT1(API2-MALT1) t(11;18) RT-PCR 81479
0056008 ETV6-RUNX1 (TEL-AML1) t(12;21) RT-PCR 81401
0060110 Culture, Neisseria gonorrhoeae 87081; Identification CPT codes may vary based on method
0060113 Culture, Legionella species 87081; Identification CPT codes may vary based on method
0060117 Culture, Bordetella pertussis 87081; Identification CPT codes may vary based on method
0060124 Culture, Staphylococcus 87081; Identification CPT codes may vary based on method
0060126 Culture, Streptococcus (Group A) 87081; Identification CPT codes may vary based on method
0060131 Culture, Urine 87088; Identification CPT codes may vary based on method
0060159 Culture, Brucella 87081; Identification CPT codes may vary based on method
0060360 Culture, Corynebacterium diphtheriae 87081; Identification CPT codes may vary based on method
0060363 Culture, Vanco-Resistant Enterococcus 87081; Identification CPT codes may vary based on method
0070263 Leptin Quant by CIA 82397
0080108 Maternal Serum Screen AFP, hCG, Estriol (82105; 84702; 82677) or 81510*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
0080269 Maternal Serum Screen AFP, hCG, EST, INH (82105; 84702;82677;86336) or 81511*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
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0081064 Maternal Screening, INT-2 (82105; 84702;82677;86336) or 81511*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
0081150 Maternal Serum, First Trimester (84702;84163) or 81508*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
0081293 Maternal Screening, Sequential, Spec 1 (84702;84163) or 81508*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
0081294 Maternal Screening, Sequential, Spec 2 (82105; 84702;82677;86336) or 81511*
*The 2014 AMA CPT manual contains the component CPT Codes and the new MAAA codes. Please direct any questions regarding CPT coding to the payer being billed.
0090050 Caffeine Level 80155
0090057 Gabapentin Level 80171
0090102 Doxepin and Metabolite, Serum or Plasma 80166
0090177 Lamotrigine 80175
0090213 Mycophenolic Acid 80180
0091541 Tiagabine, Serum or Plasma 80199
0092118 Everolimus 80169
0092209 CBFB-MYH11, inv(16) by RT-PCR 81401
0092660 Vascular Endothelial Growth Factor 82397
0095862 Lymphocyte Subset 6, with CD45RA/CD45RO 86355; 86357; 86359; 86360; 86356 x2
0095899 Lymphocyte Subset 7, Congenital Immun. 86355; 86357; 86359; 86360; 86356 x4
0097908 Zonisamide Quantitative 80203
0098627 Keppra (Levetiracetam) 80177
0098834 Oxcarbazepine Metabolite 80183
0098930 Clozapine 80159
2001932 KRAS Mutation Detection with BRAF Reflex 88381; 81275; 81403; If reflexed, add 81210 2001971 JPS (SMAD4) Sequencing and Del/Dup 81405; 81406
2001976 JPS (SMAD4) Deletion/Duplication 81405
2002005 Pancreatitis (CFTR, PRSS1, SPINK1) Seq 81223; 81404 x2
2002012 Pancreatitis, Idiopathic (SPINK1) Seq 81404
2002064 Chimerism Post-Transplant, Sorted Cells 81268; If sorted cells is performed, BMT will be billed additionally using CPT 88184; 88185
2002123 Allergen, Inhalants, Pro 28 86003 x27; 86005
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2002287 Chromosome Analysis Rule Out Mosaicism 88230; 88263; 88291
2002291 Chromosome Analysis Chorionic Villus 88269; 88235; 88291
2002297 Chromosome FISH Prenatal 88271 x5; 88275 x5; 88291
2002301 Microarray Family Study by FISH 88230; 88271; 88273; 88291
2002327 Mismatch Repair IHC with Reflex to BRAF 88342 x4; if reflexed, add 88381, 81210; if further reflexed, add 81479
2002357 JAK2 Exon 12 Mutation Analysis by PCR 81403
2002394 Alport Syndrome (COL4A5) Del/Dup 81407
2002398 Alport Syndrome (COL4A5) Seq and Del/Dup 81407; 81408
2002437 KIT Mutations in AML 81404
2002440 EGFR by Pyrosequencing 88381; 81235
2002498 BRAF Codon 600 Mutation Detection 88381; 81210
2002499 MLH1 Methylation by PCR 88381; 81479
2002674 Gastrointestinal Stromal Tumor Mutation 88381; 81404 x2
2002695 KIT Mutations, Melanoma 88381; 81404
2002871 PML-RARA Translocation, t(15;17) Quant 81315
2003123 NRAS Mutation Detection, Pyrosequencing 88381; 81404
2003243 SEPT9 Methylated DNA Detection 81401
2003401 PAH (BMPR2) Deletion/Duplication 81405
2003405 PAH (BMPR2) Seq and Del/Dup 81405; 81406
2003410 PAH (BMPR2) Sequencing 81406
2004115 PTEN by IHC 88360
2004203 PCD (SLC22A5) Seq and Del/Dup 81405; 81479
2004247 CEBPA Mutation Detection 81403
2004510 PIK3CA Mutation Detection 88381; 81479
2004516 Estrogen Receptor by IHC 88360
2004519 Ki-67, MIB-1 by IHC 88360
2004522 p53 by IHC 88360
2004525 Progesterone Receptor by IHC 88360
2004680 IL28B-Associated Variants, 2 SNPs 81400
2004745 FibroSURE 0001M
2004924 BCR-ABL1, T315I Mutation Detection, Quantitative 81401
2004927 CDKL5-Related Disorders (CDKL5) Del/Dup 81405
2004935 CDKL5-Related Disorders Seq and Del/Dup 81405; 81406
2005010 BCR-ABL1, Qualitative with Quant Reflex 81206; 81207; If reflexed, add 81206 or 81207 2005016 BCR-ABL1, Minor (p190), Quantitative 81207
2005017 BCR-ABL1, Major (p210), Quantitative 81206
2005018 Celiac HLA-DQA1*05, DQB1*02, DQB1*03:02 81376 x2
2005270 Mismatch Repair IHC with Reflex to MLH1 88342 x4; if reflexed, add 88381, 81479
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2005490 VWD Type 2M (VWF) Sequencing 81404
2005506 Trichomonas vaginalis by TMA 87661
2005545 MPL codon 515 Mutation Detection, Quant 81402
2005766 WT1 Mutation Detection 81479
2006050 Mito Disorders (108 Nuc. Genes) Seq. 81404 x9 (C10of2; COX6B1; CPT2; FXN; NDUFA1; NDUFS4; SCO2; SDHD; SLC25A5)
81405 x23 (ACADS; APTX; BCKDHA; BCSIL; COX10; COX15; DGUOK; FH; MPV17; NDUFS7; NDUFS8; NDUFV1; PDHB; PINK1; RRM2B; SCO1; SDHB; SDHC; SLC22A5; SLC25A20; SURF1; TK2; TYMP)
81406 x17 (ACADVL; ASS1; BCKHB; CPT1A; DBT; DLAT; DLD; HADHB; MCCC2; MFN2; NDUFS1; PC, PDHX, POLG, SDHA, SPG7, TAZ)
81407 (OPA1)
81479
2006054 Mito Disord Panel (mtDNA-108 Nuc Genes) 81403 x2 (MT-RNR1; MT-TS1)
81404 x11 (C10of2; COX6B1; CPT2; FXN; NDUFA1; NDUFS4; SCO2; SDHB (del); SDHC (del); SDHD; SLC25A5)
81405 x26 (ACADS; APTX; BCKDHA; BCSIL; COX10; COX15; DBT; DGUOK; FH; MPV17; NDUFS7; NDUFS8; NDUFV1; PDHB; PINK1; RRM2B; SCO1; SDHB; SDHC; SLC22A5; SLC25A20; SPG7; SURF1; TK2; TYMP; Mito del/dup)
81406 x19 (ACADVL; ASS1; BCKHB; CPT1A; DBT; DLAT; DLD; HADHA; HADHB; MCCC2; MFN2;NDUFS1; OPA1; PC; PDHX; POLG; SDHA; SPG7; TAZ)
81407 (OPA1)
81479 x2
2006061 mtDNA Genome and 108 Nuc. Genes Del/Dup 81404 x2 (SDHC, SLC25A20);
81405 x3 (DBT, Mito Genome DD, SPG7) 81406 (OPA1)
81479
2006193 B-Cell Clonality Screening (IgH and IgK) 81261; 81264
2006258 Sexually Transmitted Disease Panel 1 87491; 87591; 87661
2006301 Gabapentin Quantitative, Urine 80171
2006444 IDH1 and IDH2 Mutation Analysis, exon 4 81403 x2; FFPE tumor tissue, add 88381 2006516 BRAF V600E Mutation Detection, FNA 88381; 81210
2006540 Aortopathy Panel, Seq and Del/Dup 81405 x4 (ACTA2; SMAD4; TGFRB1; TGFRB2) 81406 x2 (CBS; SMAD4)
81408 x2 (FBN1; MYH11) 81479 x2
2006546 Aortopathy Del/Dup, 17 Genes 81405 (SMAD4)
81479
2006617 Aortopathy Sequencing, 17 Genes 81405 x3 (ACTA2; TGFRB1; TGFRB2) 81406 x2 (CBS; SMAD4)
81408 x2 (FBN1; MYH11) 81479
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2006621 Drug Detection Pan, TOF, Umbilical 80100 x2; 80101
2006872 Mito Disorders (mtDNA) Seq and DelDup 81403x2 (MT-RNR1; MT-TS1)
81405
81479 x2
2006878 Mito Disorders Nuclear Seq and DelDup 81404 x11 (C10of2, COX6B1, CPT2, FXN, NDUFA1, NDUFS4, SCO2, SDHC (del), SDHD, SLC25A20, SLC25A4)
81405 x25 (ACADS, APTX, BCKDHA, BCS1L, COX10, COX15, DBT, DGUOK, FH, MPV17, NDUFS7, NDUFS8, NDUFV1, PDHB, PINK1, RRM2B, SCO1, SDHB, SDHC, SLC22A5, SLC25A20, SPG7, SURF1, TK2, TYMP)
81406 x19(ACADVL, ASS1, BCKHB, CPT1A, DBT, DLAT, DLD, HADHA, HADHB, MCCC2, MFN2, NDUFS1, OPA1, PC, PDHX,
POLG, SDHA, SPG7, TAZ) 81407 (OPA1)
81479 x2
2006889 Cytology, FNA w/Rflx BRAF V600E, Request FNA-codes; if reflexed, add 88381; 81210
2007069 Citrullinemia, Type I (ASS1) Sequencing 81406
2007085 Retinitis Pigmentosa, Seq and Del/Dup 81404 x4 (CRX; PRPH2; RHO; RP) 81406 x3 (BEST1; CRB1; RPE65)
81408 x3 ( ABCA4; CEP290; USH2A)
81479 x2
2007091 Retinitis Pigmentosa Sequencing 81404 x4 (CRX; PRPH2; RHO; RP) 81406 x3 (BEST1; CRB1; RPE65)
81408 x3 (ABCA4; CEP290; USH2A)
81479 2007113 HPGL-PCC (SDHB,C,D) Deletion/Duplication 81404; 81479 2007117 HPGL-PCC (SDHC) Seq and DelDup 81404; 81405 2007132 BRAF V600E Detection Hairy Cell, Quant 81210
2007167 HPGL-PCC (SDHB,C,D) Seq and DelDup Panel 81404 x2; 81405 x2; 81479
2007329 ERBB2 (HER2) (4B5) by IHC 88360
2007332 ERBB2 (HER2) (HercepTest) by IHC 88360
2007361 Parasite Examination, Macroscopic 87169
2007380 Vascular Malformations Del/Dup, 10 Genes 81323
81405 x2 (ENG; SMAD4)
81479
2007384 Vasc Malformation Panel, Seq and Del/Dup 81321 (PTEN) 81323 (PTEN del)
81405 x2 (BMPR2; ENG) 81406 x2 (PMPR2; ENG)
81479 x2 2007390 Vascular Malformations Sequencing 81321 (PTEN)
81406 x2 (BMPR2; ENG)
81479 2007401 Succinylacetone, Quantitative, Urine 83921
2007880 Alpha Subunit, Pit. Glycoprotein Horm. 82397
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2007914 EPOR Mutation Detection by Sequencing 81479
2007991 Solid Tumor Mutation Panel by NGS 81210 (BRAF) 81235 (EGFR) 81275 (KRAS) 81310 (NPM1) 81402 (MPL)
81403 x6 (ABL1; CTNNB1; HRAS; IDH1; IDH2;KRAS) 81404 x6 ( FGFR2; FGFR3; KIT; NRAS; PDGFRA; RET) 81405 (TP53)
81479; 88381
2008116 Urine Culture, Invasive Collection 87088; Identification CPT codes may vary based on method
2008377 Peutz-Jeghers Syndrome (STK11) DelDup 81404
2008394 Peutz-Jeghers Syndrome (STK11) Seq 81405
2008398 Peutz-Jeghers Synd (STK11) Seq, DelDup 81404; 81405
2008409 T-Cell Clonality by NGS 81342
2008420 BCR-ABL1 Mutation Analysis by NGS 81403
2008426 Statin Sensitivity (SLCO1B1), 1 Variant 81400
2008476 Culture, Fluoroquinolone-Rstnt Org 87081; Identification CPT codes may vary based on method
2008803 Expanded Hearing Loss Panel, Seq/DelDup 81252 (GJB2) 81254 (GJB6) 81404 x2 (CLRN1; USH1G) 81405 (DFNB59) 81406 x2 (PCDH15; SLC26A4) 81407 x3 (MYO7A; PCDH15; USH1C) 81408 x2 (CDH23; USH2A) 81479x2 2008808 Expanded Hearing Loss Panel Del/Dup 81406 (PCDH15)
81479 2008831 Metabolic Storage Disorders Sequencing 81250 (G6PC)
81251 (GBA) 81290 (MCOLN1) 81330 (SMPD1)
81404 (NPC2)
81405 x3 (ARSA; GLA; IDS)
81406 x5 (GAA; GALC; IDUA; NPC1; PYGM; SLC37A4)
81407 (AGL)
81479
